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Título: | 4-Hydroxydibenzyl: a novel metabolite from the human gut microbiota after consuming resveratrol |
Autor: | Iglesias-Aguirre, Carlos E.; Vallejo, Fernando CSIC ORCID; Beltrán Riquelme, David; Berná, José; Puigcerver, J.; Alajarín, Mateo; Selma, María Victoria CSIC ORCID ; Espín de Gea, Juan Carlos CSIC ORCID | Fecha de publicación: | 23-jun-2022 | Editor: | Royal Society of Chemistry (UK) | Citación: | Food & function 13: 7487-7493 (2022) | Resumen: | Resveratrol (RSV) was known to be metabolised by the gut microbiota to dihydroresveratrol, lunularin (LUNU), and (or) 3,4′-dihydroxy-trans-stilbene (DHST). We describe here for the first time that LUNU can be further dehydroxylated, but only at the 3-position, to yield 4-hydroxydibenzyl, a novel metabolite found in human urine after RSV intake in 41 out of 59 healthy participants. In contrast, DHST was not further dehydroxylated, and thus, 4-hydroxy-trans-stilbene was not detected as a gut microbial metabolite of RSV. Faecal in vitro incubations confirmed the in vivo results. | Versión del editor: | http://dx.doi.org/10.1039/d2fo01475k | URI: | http://hdl.handle.net/10261/283676 | DOI: | 10.1039/d2fo01475k | Identificadores: | doi: 10.1039/d2fo01475k issn: 2042-650X |
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Iglesias2022FundFunt.pdf | 500,99 kB | Adobe PDF | Visualizar/Abrir |
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