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http://hdl.handle.net/10261/271612
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Aleixandre, Andrea | es_ES |
dc.contributor.author | Gisbert, Mauro | es_ES |
dc.contributor.author | Sineiro, Jorge | es_ES |
dc.contributor.author | Moreira, Ramón | es_ES |
dc.contributor.author | Rosell, Cristina M. | es_ES |
dc.date.accessioned | 2022-06-06T06:09:35Z | - |
dc.date.available | 2022-06-06T06:09:35Z | - |
dc.date.issued | 2022-05-19 | - |
dc.identifier.citation | Journal of Food Science 87 (6): 2405-2416 (2022) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10261/271612 | - |
dc.description.abstract | Seaweeds are gaining importance due to their antidiabetic characteristics. This study investigated the inhibitory effects of aqueous Ascophyllum nodosum extracts, obtained by ultrasound-assisted extraction with different sonication powers (70-90 W/cm2 ) and subjected to resin purification, against α-amylase and α-glucosidase enzymes. Different inhibition methodologies were carried out, preincubating the extract either with the enzyme or the substrate. Chemical characterization, in terms of proximate analysis, antioxidant capacity (2,2-diphenyl-1-picryl-hydrazyl-hydrate [DPPH] and FRAP), and polyphenols characteristics (reversed-phase high-performance liquid chromatography [RP-HPLC] and 1 H-NMR) were carried out to explain inhibitory activities of extracts. Sonication power did not influence the proximal composition nor antiradical activity of extracts, but increasing sonication power increased inhibition capacity (>15%) against both starch digestive enzymes. The extract purification largely improved the inhibition efficiency decreasing the IC50 of α-amylase and α-glucosidase by 3.0 and 6.1 times, respectively. Seaweed extracts showed greater inhibition effect when they were preincubated with the enzyme instead of the substrate. RP-HPLC together with 1 H-NMR spectra allowed relating the presence of uronic acids-polyphenols complexes and quinones in the extracts with the different inhibitory capacities of samples. PRACTICAL APPLICATION: The study confirms that ultrasound-assisted extracts from Ascophyllum nodosum can be used to inhibit digestive enzymes. This opens the alternative to be used in foods for modulating glycemic index. | es_ES |
dc.description.sponsorship | Authors acknowledge the financial support of Grant RTI2018-095919-B-C2 funded by MCIN/AEI/10.13039/501100011033, “ERDF A way of making Europe” by the “European Union,” Generalitat Valenciana (Project Prometeo 2017/189) and Xunta de Galicia (ED431B 2019/01). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | John Wiley & Sons | es_ES |
dc.publisher | Institute of Food Technologists | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-095919-B-C21/ES/INCORPORACION DE FLOROTANINOS Y ALMIDON PARA OBTENER ALIMENTOS LIBRES DE GLUTEN SALUDABLES DIRIGIDOS AL CONTROL DE LA RESPUESTA GLICEMICA/ | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-095919-B-C22/ES/AISLAMIENTO Y CARACTERIZACION DE FLOROTANINOS COMO ANTIOXIDANTES, AGENTES DE ENTRECRUZAMIENTO E INHIBIDORES ENZIMATICOS EN MATERIALES AMILACEOS/ | es_ES |
dc.relation.ispartof | Journal of food science | es_ES |
dc.relation.isversionof | Publisher's version | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | 1H-NMR | es_ES |
dc.subject | HPLC | es_ES |
dc.subject | Gelled starch | es_ES |
dc.subject | Wheat | es_ES |
dc.subject | α-amylase | es_ES |
dc.subject | α-glucosidase | es_ES |
dc.title | In vitro inhibition of starch digestive enzymes by ultrasound-assisted extracted polyphenols from Ascophyllum nodosum seaweeds | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1111/1750-3841.16202 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1111/1750-3841.16202 | es_ES |
dc.rights.license | http://creativecommons.org/licenses/by-nc-nd/4.0/ | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | Generalitat Valenciana | es_ES |
dc.contributor.funder | Xunta de Galicia | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100010801 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003359 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.identifier.pmid | 35590486 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
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JFScience-2022-Aleixandre.pdf | Artículo principal | 1,07 MB | Adobe PDF | Visualizar/Abrir |
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