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Título: | Multi-residue extraction to determine organic pollutants in mussel hemolymph |
Autor: | Álvarez-Ruiz, R. CSIC ORCID CVN; Picó, Yolanda CSIC ORCID; Campo, Julián CSIC ORCID | Palabras clave: | Illicit drugs Perfluoroalkyl substances Pesticides Pharmaceuticals Solid-phase extraction |
Fecha de publicación: | abr-2021 | Editor: | Wiley-VCH | Citación: | Journal of Separation Science 44(8): 1641-1651 (2021) | Resumen: | This study assesses the extraction of eleven pharmaceuticals, five pesticides, five perfluoroalkyl substances, and two illicit drugs in hemolymph from (Mytilus Galloprovincialis). Four extraction procedures using Phree™ Phospholipid Removal cartridges were tested using different volumes of methanol (400 and 600 μL) and acetonitrile (300 and 450 μL). The pollutants were determined by high-performance liquid chromatography–tandem mass spectrometry. The use of methanol gave several problems during the extraction procedure, such as longer times and sample loss. Three methods (acetonitrile 300 and 450 μL; and methanol 600 μL) were validated. Recoveries at three concentration levels (5, 50, and 100 ng/mL) ranged 35.1–129.0 and 29.3–133.0% for acetonitrile 300 and 450 μL, respectively, while recoveries for methanol 600 μL ranged 52.2–166.0%. Limits of detection were < 10 ng/mL for most analytes using any of the methods. Methanol 600 μL was the only method capable to extract the illicit drug 4-methoxyphencyclidine and provided a better peak shape and higher signal-noise ratio. When applied to non-spiked samples from local markets salicylic acid and diclofenac were detected at 33.50-97.79 and 28.30-30.31 ng/mL respectively. To our knowledge, there are no methods to determine organic contaminants in hemolymph and this is the first application of Phree™ cartridges for mussel hemolymph extraction. | Versión del editor: | http://dx.doi.org/10.1002/jssc.202001211 | URI: | http://hdl.handle.net/10261/266527 | DOI: | 10.1002/jssc.202001211 | ISSN: | 1615-9306 | E-ISSN: | 1615-9314 |
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Multi-residue_extraction_Álvarez_Preprint_Art2021.pdf | 652,99 kB | Adobe PDF | Visualizar/Abrir |
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