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Título: | Comparative Venomics of the Cryptic Cone Snail Species Virroconus ebraeus and Virroconus judaeus |
Autor: | Pardos-Blas, José Ramón CSIC ORCID ; Tenorio, Manuel J.; Galindo, Juan Carlos G.; Zardoya, Rafael CSIC ORCID | Palabras clave: | Cone snails Conotoxins; venom duct transcriptomes Venom duct proteomes Virroconus ebraeus Virroconus judaeus Differential expression Cerm03 SF-mi2 Insulin |
Fecha de publicación: | 17-feb-2022 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | Marine Drugs 20: 149 (2022) | Resumen: | The venom duct transcriptomes and proteomes of the cryptic cone snail species Virroconus ebraeus and Virroconus judaeus were obtained and compared. The most abundant and shared conotoxin precursor superfamilies in both species were M, O1, and O2. Additionally, three new putative conotoxin precursor superfamilies (Virro01-03) with cysteine pattern types VI/VII and XVI were identified. The most expressed conotoxin precursor superfamilies were SF-mi2 and M in V. ebraeus, and Cerm03 and M in V. judaeus. Up to 16 conotoxin precursor superfamilies and hormones were differentially expressed between both species, and clustered into two distinct sets, which could represent adaptations of each species to different diets. Finally, we predicted, with machine learning algorithms, the 3D structure model of selected venom proteins including the differentially expressed Cerm03 and SF-mi2, an insulin type 3, a Gastridium geographus GVIA-like conotoxin, and an ortholog to the Pionoconus magus ω-conotoxin MVIIA (Ziconotide). | Versión del editor: | https://www.mdpi.com/1660-3397/20/2/149 | URI: | http://hdl.handle.net/10261/264438 | DOI: | 10.3390/md20020149 | E-ISSN: | 1660-3397 |
Aparece en las colecciones: | (MNCN) Artículos |
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Zardoya_R_Comparative.pdf | Artículo principal | 2,09 MB | Adobe PDF | Visualizar/Abrir |
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