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Título: | Can Plasma α-Synuclein Help Us to Differentiate Parkinson’s Disease from Essential Tremor? |
Autor: | Albillos, Silvia M.; Montero, Olimpio CSIC ORCID CVN ; Calvo, Sara; Solano, Berta; Trejo-Gabriel-Galán, José María; Cubo, Esther | Palabras clave: | Parkinson’s disease Essential tremor Alpha-synuclein Plasma biomarker Diagnosis |
Fecha de publicación: | 2021 | Editor: | Ubiquity Press | Citación: | Tremor and Other Hyperkinetic Movements 11: 1- 8 (2021) | Resumen: | [Background]: Studies have revealed controversial results regarding the diagnostic accuracy of plasma α-synuclein levels in patients with Parkinson’s disease (PD). This study was aimed to analyze the diagnostic accuracy of plasma α-synuclein in PD versus healthy controls and patients with essential tremor (ET). [Methods]: In this cross-sectional study, we included de novo (n = 19) and advanced PD patients [OFF (n = 33), and On (n = 35) states], patients with ET (n = 19), and controls (n = 35). The total plasma α-synuclein levels were determined using an ELISA sandwich method. We performed adjusted multivariate regression analysis to estimate the association of α-synuclein levels with group conditions [controls, ET, and de novo, OFF and ON-PD]. We studied the diagnostic accuracy of plasma α-synuclein using the area under the curve (AUC). [Results]: The plasma α-synuclein levels were higher in controls compared to PD and ET (p < 0.0001), discriminating de novo PD from controls (AUC = 0.74, 95% CI 0.60–0.89), with a trend towards in advanced PD (OFF state) from ET (AUC = 0.69, 95% CI 0.53–0.84). Conclusions: This is the first study examining and comparing plasma α-synuclein levels in ET vs. PD and controls. Preliminary findings suggest that plasma α-synuclein levels might help to discriminate de novo and advanced PD from controls and ET. | Descripción: | © 2021 The Author(s). | Versión del editor: | http://dx.doi.org/10.5334/tohm.600 | URI: | http://hdl.handle.net/10261/260671 | DOI: | 10.5334/tohm.600 | E-ISSN: | 2160-8288 |
Aparece en las colecciones: | (IBGM) Artículos |
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Can Plasma_Albillos_PV_Art2021.pdf | 1,35 MB | Adobe PDF | Visualizar/Abrir |
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