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http://hdl.handle.net/10261/256405
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Gómez-Ruiz, José Ángel | - |
dc.contributor.author | Taborda, Gonzalo | - |
dc.contributor.author | Amigo, Lourdes | - |
dc.contributor.author | Recio, Isidra | - |
dc.contributor.author | Ramos González, María Mercedes | - |
dc.date.accessioned | 2021-12-17T13:00:03Z | - |
dc.date.available | 2021-12-17T13:00:03Z | - |
dc.date.issued | 2006-03-21 | - |
dc.identifier | doi: 10.1007/s00217-005-0238-0 | - |
dc.identifier | issn: 1438-2377 | - |
dc.identifier | e-issn: 1438-2385 | - |
dc.identifier.citation | European Food Research and Technology 223: 595- 601 (2006) | - |
dc.identifier.uri | http://hdl.handle.net/10261/256405 | - |
dc.description.abstract | Different Spanish cheeses (Cabrales, Idiazábal, Roncal, Manchego, Mahón and a goat's milk cheese), made with diverse technologies and milk from different species, were studied for their angiotensin converting enzyme (ACE)-inhibitory activity. Among the water-soluble extract WSE<1000-Da of the different samples, Cabrales cheese was the most active with an inhibitory activity of 76.1%. On the contrary, Mahón cheese showed the lowest ACE-inhibitory index (56.6%). In order to identify the peptides involved in this activity, the WSE<1000-Da were analyzed by HPLC-MS/MS and off-line MS/MS. A total of 41 major peptides were identified in the different cheeses. Most of them derived from β-and αs1-casein. Several of these peptides were selected on the basis of the presence of proline as the C-terminal amino acid, and they were chemically synthesized. All peptides showed moderate or low ACE-inhibitory activity. Peptide DKIHP [β-CN f(47–51)], a sequence detected in all samples except Mahón cheese, showed the highest inhibitory activity with an IC50 value of 113.1 μM. | - |
dc.description.sponsorship | This work has received financial support from project AGL-2004-06903-C02-01. J.A. Gómez-Ruiz was the recipient of a fellowship from the Comunidad Autónoma de Madrid, Spain. G. Taborda expresses his appreciation to Colciencias for a fellowship and to the Universidad de Caldas (Manizales, Colombia). | - |
dc.language | eng | - |
dc.publisher | Springer Nature | - |
dc.relation | info:eu-repo/grantAgreement/MINECO//AGL-2004-06903-C02-01 | - |
dc.rights | closedAccess | - |
dc.subject | Bioactive peptides | - |
dc.subject | ACE-inhibitory activity | - |
dc.subject | HPLC-MS/MS | - |
dc.subject | PDO Spanish cheeses | - |
dc.title | Identification of ACE-inhibitory peptides in different Spanish cheeses by tandem mass spectrometry | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1007/s00217-005-0238-0 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1007/s00217-005-0238-0 | - |
dc.date.updated | 2021-12-17T13:00:03Z | - |
dc.contributor.funder | Ministerio de Educación y Ciencia (España) | - |
dc.contributor.funder | Comunidad de Madrid | - |
dc.contributor.funder | Colciencias (Colombia) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/100012818 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
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