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| Título: | Transgenic mouse models with tau pathology to test therapeutic agents for Alzheimer's disease |
Autor: | Hernández, Félix; Lim, Filip CSIC ORCID; Lucas, José Javier CSIC ORCID; Pérez Martín, María Concepción; Moreno, Francisco J.; Ávila, Jesús CSIC ORCID | Palabras clave: | Tau pathology Tau hyperphosphorylation Alzheimers disease |
Fecha de publicación: | 2003 | Editor: | Bentham Science Publishers | Citación: | Mini-Reviews in Medicinal Chemistry 2(1): 51-58 (2002) | Resumen: | The deposit of two proteins in the brain characterizes Alzheimers disease: deposits of β-amyloid protein to form senile plaques and tau protein in neurofibrillary tangles. This review discusses transgenic animals overexpressing normal or mutated tau protein as well as kinases involved in tau hyperphosphorylation. These animals hold a great potential as tools to test the effects of forthcoming therapeutical agents for Alzheimers disease. | Descripción: | open access plus | Versión del editor: | https://doi.org/10.2174/1389557023406557 | URI: | http://hdl.handle.net/10261/251567 | DOI: | 10.2174/1389557023406557 | ISSN: | 1389-5575 |
| Aparece en las colecciones: | (CBM) Artículos |
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|---|---|---|---|---|
| transgenidisea.pdf | 66,66 kB | Adobe PDF |  Visualizar/Abrir |
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