Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/25042
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | CCAAT/enhancer binding protein beta deficiency provides cerebral protection following excitotoxic injury |
Autor: | Cortés-Canteli, Marta CSIC ORCID; Luna Medina, Rosario de CSIC; Sanz-SanCristóbal, Marina CSIC; Álvarez Barrientos, Alberto; Santos, Ángel; Pérez Castillo, Ana CSIC ORCID | Palabras clave: | C/EBPβ Excitotoxicity Inflammation Neurodegeneration |
Fecha de publicación: | 15-abr-2008 | Editor: | Company of Biologists | Citación: | Journal of Cell Science 121(8): 1224-1234 (2008) | Resumen: | The CCAAT/enhancer-binding protein beta (C/EBPbeta, also known as CEBPB) was first identified as a regulator of differentiation and inflammatory processes in adipose tissue and liver. Although C/EBPbeta was initially implicated in synaptic plasticity, its function in the brain remains largely unknown. We have previously shown that C/EBPbeta regulates the expression of genes involved in inflammatory processes and brain injury. Here, we have demonstrated that the expression of C/EBPbeta is notably increased in the hippocampus in a murine model of excitotoxicity. Mice lacking C/EBPbeta showed a reduced inflammatory response after kainic acid injection, and exhibited a dramatic reduction in pyramidal cell loss in the CA1 and CA3 subfields of the hippocampus. These data reveal an essential function for C/EBPbeta in the pathways leading to excitotoxicity-mediated damage and suggest that inhibitors of this transcription factor should be evaluated as possible neuroprotective therapeutic agents. | Descripción: | 11 pages, 7 figures.-- Supplementary material available online at http://jcs.biologists.org/cgi/content/full/121/8/1224/DC1 | Versión del editor: | http://dx.doi.org/10.1242/jcs.025031 | URI: | http://hdl.handle.net/10261/25042 | DOI: | 10.1242/jcs.025031 | ISSN: | 0021-9533 |
Aparece en las colecciones: | (IIBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
CCAAT Enhancer Binding.pdf | 8,38 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
54
checked on 08-may-2024
WEB OF SCIENCETM
Citations
54
checked on 28-feb-2024
Page view(s)
410
checked on 15-may-2024
Download(s)
412
checked on 15-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.