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dc.contributor.authorCortés-Canteli, Marta-
dc.contributor.authorLuna Medina, Rosario de-
dc.contributor.authorSanz-SanCristóbal, Marina-
dc.contributor.authorÁlvarez Barrientos, Alberto-
dc.contributor.authorSantos, Ángel-
dc.contributor.authorPérez Castillo, Ana-
dc.date.accessioned2010-06-07T09:42:38Z-
dc.date.available2010-06-07T09:42:38Z-
dc.date.issued2008-04-15-
dc.identifier.citationJournal of Cell Science 121(8): 1224-1234 (2008)en_US
dc.identifier.issn0021-9533-
dc.identifier.urihttp://hdl.handle.net/10261/25042-
dc.description11 pages, 7 figures.-- Supplementary material available online at http://jcs.biologists.org/cgi/content/full/121/8/1224/DC1en_US
dc.description.abstractThe CCAAT/enhancer-binding protein beta (C/EBPbeta, also known as CEBPB) was first identified as a regulator of differentiation and inflammatory processes in adipose tissue and liver. Although C/EBPbeta was initially implicated in synaptic plasticity, its function in the brain remains largely unknown. We have previously shown that C/EBPbeta regulates the expression of genes involved in inflammatory processes and brain injury. Here, we have demonstrated that the expression of C/EBPbeta is notably increased in the hippocampus in a murine model of excitotoxicity. Mice lacking C/EBPbeta showed a reduced inflammatory response after kainic acid injection, and exhibited a dramatic reduction in pyramidal cell loss in the CA1 and CA3 subfields of the hippocampus. These data reveal an essential function for C/EBPbeta in the pathways leading to excitotoxicity-mediated damage and suggest that inhibitors of this transcription factor should be evaluated as possible neuroprotective therapeutic agents.en_US
dc.description.sponsorshipThis work was supported by the Ministerio de Educacion y Ciencia grants SAF2004-06263-CO2-01 and SAF2007-62811 (to A.P.-C.) and SAF2004-06263-CO2-02 (to A.S.) and the Comunidad de Madrid grant GR/SAL/0033/2004 (to A.P.-C.). M.C.-C. is a post-doctoral fellow of the Consejo Superior de Investigaciones Científicas. R.L.-M is a fellow from the Ministerio de Educación y Ciencia.en_US
dc.format.extent3762200 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoengen_US
dc.publisherCompany of Biologistsen_US
dc.relation.isversionofPostprint-
dc.rightsopenAccessen_US
dc.subjectC/EBPβen_US
dc.subjectExcitotoxicityen_US
dc.subjectInflammationen_US
dc.subjectNeurodegenerationen_US
dc.titleCCAAT/enhancer binding protein beta deficiency provides cerebral protection following excitotoxic injuryen_US
dc.typeartículoen_US
dc.identifier.doi10.1242/jcs.025031-
dc.description.peerreviewedPeer revieweden_US
dc.relation.publisherversionhttp://dx.doi.org/10.1242/jcs.025031en_US
dc.contributor.funderMinisterio de Educación y Ciencia (España)-
dc.contributor.funderComunidad de Madrid-
dc.contributor.funderConsejo Superior de Investigaciones Científicas (España)-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003339es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100012818es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
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