Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/25042
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Cortés-Canteli, Marta | - |
dc.contributor.author | Luna Medina, Rosario de | - |
dc.contributor.author | Sanz-SanCristóbal, Marina | - |
dc.contributor.author | Álvarez Barrientos, Alberto | - |
dc.contributor.author | Santos, Ángel | - |
dc.contributor.author | Pérez Castillo, Ana | - |
dc.date.accessioned | 2010-06-07T09:42:38Z | - |
dc.date.available | 2010-06-07T09:42:38Z | - |
dc.date.issued | 2008-04-15 | - |
dc.identifier.citation | Journal of Cell Science 121(8): 1224-1234 (2008) | en_US |
dc.identifier.issn | 0021-9533 | - |
dc.identifier.uri | http://hdl.handle.net/10261/25042 | - |
dc.description | 11 pages, 7 figures.-- Supplementary material available online at http://jcs.biologists.org/cgi/content/full/121/8/1224/DC1 | en_US |
dc.description.abstract | The CCAAT/enhancer-binding protein beta (C/EBPbeta, also known as CEBPB) was first identified as a regulator of differentiation and inflammatory processes in adipose tissue and liver. Although C/EBPbeta was initially implicated in synaptic plasticity, its function in the brain remains largely unknown. We have previously shown that C/EBPbeta regulates the expression of genes involved in inflammatory processes and brain injury. Here, we have demonstrated that the expression of C/EBPbeta is notably increased in the hippocampus in a murine model of excitotoxicity. Mice lacking C/EBPbeta showed a reduced inflammatory response after kainic acid injection, and exhibited a dramatic reduction in pyramidal cell loss in the CA1 and CA3 subfields of the hippocampus. These data reveal an essential function for C/EBPbeta in the pathways leading to excitotoxicity-mediated damage and suggest that inhibitors of this transcription factor should be evaluated as possible neuroprotective therapeutic agents. | en_US |
dc.description.sponsorship | This work was supported by the Ministerio de Educacion y Ciencia grants SAF2004-06263-CO2-01 and SAF2007-62811 (to A.P.-C.) and SAF2004-06263-CO2-02 (to A.S.) and the Comunidad de Madrid grant GR/SAL/0033/2004 (to A.P.-C.). M.C.-C. is a post-doctoral fellow of the Consejo Superior de Investigaciones Científicas. R.L.-M is a fellow from the Ministerio de Educación y Ciencia. | en_US |
dc.format.extent | 3762200 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | en_US |
dc.publisher | Company of Biologists | en_US |
dc.relation.isversionof | Postprint | - |
dc.rights | openAccess | en_US |
dc.subject | C/EBPβ | en_US |
dc.subject | Excitotoxicity | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Neurodegeneration | en_US |
dc.title | CCAAT/enhancer binding protein beta deficiency provides cerebral protection following excitotoxic injury | en_US |
dc.type | artículo | en_US |
dc.identifier.doi | 10.1242/jcs.025031 | - |
dc.description.peerreviewed | Peer reviewed | en_US |
dc.relation.publisherversion | http://dx.doi.org/10.1242/jcs.025031 | en_US |
dc.contributor.funder | Ministerio de Educación y Ciencia (España) | - |
dc.contributor.funder | Comunidad de Madrid | - |
dc.contributor.funder | Consejo Superior de Investigaciones Científicas (España) | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003339 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100012818 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
Aparece en las colecciones: | (IIBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
CCAAT Enhancer Binding.pdf | 8,38 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
54
checked on 20-mar-2024
WEB OF SCIENCETM
Citations
54
checked on 28-feb-2024
Page view(s)
404
checked on 28-mar-2024
Download(s)
405
checked on 28-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.