Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/249202
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Overlapping of Independent SARS-CoV-2 Nosocomial Transmissions in a Complex Outbreak |
Autor: | Pérez-Lago, Laura; Martínez Lozano, Helena; Pajares Díaz, José Antonio; Díaz Gómez, Arantxa; Machado, Marina; Sola-Campoy, Pedro J.; Herranz, Marta; Valerio, Maricela; Quesada Cubo, Víctor; Gómez Ruiz, Maria del Mar; López Fresneña, Nieves; Sánchez Arcilla, Ignacio; Comas, Iñaki CSIC ORCID ; González-Candelas, Fernando CSIC ORCID; García San José, Sonia; Bañares, Rafael; Catalán, Pilar; Muñoz, Patricia; García de Viedma, Darío CSIC ORCID | Palabras clave: | COVID-19 SARS-CoV-2 Nosocomial transmission Genomic epidemiology |
Fecha de publicación: | 25-ago-2021 | Editor: | American Society for Microbiology | Citación: | mSphere 6(4):e0038921 (2021) | Resumen: | SARS-CoV-2 nosocomial outbreaks in the first COVID-19 wave were likely associated with a shortage of personal protective equipment and scarce indications on control measures. Having covered these limitations, updates on current SARS-CoV-2 nosocomial outbreaks are required. We carried out an in-depth analysis of a 27-day nosocomial outbreak in a gastroenterology ward in our hospital, potentially involving 15 patients and 3 health care workers. Patients had stayed in one of three neighboring rooms in the ward. The severity of the infections in six of the cases and a high fatality rate made the clinicians suspect the possible involvement of a single virulent strain persisting in those rooms. Whole-genome sequencing (WGS) of the strains from 12 patients and 1 health care worker revealed an unexpected complexity. Five different SARS-CoV-2 strains were identified, two infecting a single patient each, ruling out their relationship with the outbreak; the remaining three strains were involved in three independent, overlapping, limited transmission clusters with three, three, and five cases. Whole-genome sequencing was key to understand the complexity of this outbreak. IMPORTANCE We report a complex epidemiological scenario of a nosocomial COVID-19 outbreak in the second wave, based on WGS analysis. Initially, standard epidemiological findings led to the assumption of a homogeneous outbreak caused by a single SARS-CoV-2 strain. The discriminatory power of WGS offered a strikingly different perspective consisting of five introductions of different strains, with only half of them causing secondary cases in three independent overlapping clusters. Our study exemplifies how complex the SARS-CoV-2 transmission in the nosocomial setting during the second COVID-19 wave occurred and leads to extending the analysis of outbreaks beyond the initial epidemiological assumptions. | Descripción: | 8 páginas, 2 figuras, 1 tabla. | Versión del editor: | https://dx.doi.org/10.1128/mSphere.00389-21 | URI: | http://hdl.handle.net/10261/249202 | DOI: | 10.1128/mSphere.00389-21 | E-ISSN: | 2379-5042 | Referencias: | Pérez-Lago, Laura; Martínez Lozano, Helena; Pajares Díaz, José Antonio; Díaz Gómez, Arantxa; Machado, Marina; Sola-Campoy, Pedro J.; Herranz, Marta; Valerio, Maricela; Quesada Cubo, Víctor; Gómez Ruiz, Maria del Mar; López Fresneña, Nieves; Sánchez Arcilla, Ignacio; Comas, Iñaki; González-Candelas, Fernando; García San José, Sonia; Bañares, Rafael; Catalán, Pilar; Muñoz, Patricia; García de Viedma, Darío; 2021; Overlapping of independent SARS-CoV-2 nosocomial transmissions in a complex outbreak [Preprint]; Research Square; https://doi.org/10.21203/rs.3.rs-305824/v1 |
Aparece en las colecciones: | (IBV) Artículos (I2SysBio) Artículos (PTI Salud Global) Colección Especial COVID-19 |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
2021 mSphere 6-e0038921.pdf | 954,85 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
7
checked on 13-abr-2024
SCOPUSTM
Citations
8
checked on 19-abr-2024
WEB OF SCIENCETM
Citations
4
checked on 26-feb-2024
Page view(s)
136
checked on 26-abr-2024
Download(s)
167
checked on 26-abr-2024