Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/243267
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Enhanced Cytotoxic Activity of Mitochondrial Mechanical Effectors in Human Lung Carcinoma H520 Cells: Pharmaceutical Implications for Cancer Therapy |
Autor: | González Rubio, Sergio; Montero Pastor, Nuria; García Rodríguez, Carolina CSIC ORCID; Almendro-Vedia, V.G.; Ferrer, Irene; Natale, Paolo; Paz-Ares, Luis CSIC ORCID; Lillo, M. Pilar CSIC ORCID; López-Montero, Iván | Palabras clave: | NAO Mitochondrial targeting Membrane adhesion Cancer therapy NSCLC cells FLIM Phasor analysis |
Fecha de publicación: | 2018 | Citación: | Frontiers in Oncology 8 (2018) | Resumen: | Cancer cell mitochondria represent an attractive target for oncological treatment as they have unique hallmarks that differ from their healthy counterparts, as the presence of a stronger membrane potential that can be exploited to specifically accumulate cytotoxic cationic molecules. Here, we explore the selective cytotoxic effect of 10-N-nonyl acridine orange (NAO) on human lung carcinoma H520 cells and compare them with healthy human lung primary fibroblasts. NAO is a lipophilic and positively charged molecule that promotes mitochondrial membrane adhesion that eventually leads to apoptosis when incubated at high micromolar concentration. We found an enhanced cytotoxicity of NAO in H520 cancer cells. By means Fluorescence lifetime imaging microscopy (FLIM) we also confirmed the formation of H-dimeric aggregates originating fromopposing adjacent membranes that interfere with the mitochondrial membrane structure. Based on our results, we suggest the mitochondrial membrane as a potential target in cancer therapy to mechanically control the cell proliferation of cancer cells. | Descripción: | 8 pags, 5 figs | Versión del editor: | http://dx.doi.org/10.3389/fonc.2018.00514 | URI: | http://hdl.handle.net/10261/243267 | DOI: | 10.3389/fonc.2018.00514 | Identificadores: | doi: 10.3389/fonc.2018.00514 issn: 2234-943X |
Aparece en las colecciones: | (IQF) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Enhanced_Cytotoxic_Activity.pdf | 1,79 MB | Adobe PDF | Visualizar/Abrir | |
material_suplementario.docx | 1,36 MB | Microsoft Word XML | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
2
checked on 09-abr-2024
SCOPUSTM
Citations
8
checked on 23-abr-2024
WEB OF SCIENCETM
Citations
9
checked on 27-feb-2024
Page view(s)
68
checked on 27-abr-2024
Download(s)
63
checked on 27-abr-2024