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Título: | Polyethylenimine-coated superparamagnetic iron oxide nanoparticles impair in vitro and in vivo angiogenesis |
Autor: | Mulens-Arias, Vladimir CSIC ORCID ; Rojas, José M.; Sanz-Ortega, Laura; Portilla, Yadileiny; Pérez-Yagüe, Sonia; Barber, Domingo F. CSIC ORCID | Palabras clave: | Endothelial cells PEI-coated SPION Magnetic targeting Macrophage Tube formation Tumor angiogenesis |
Fecha de publicación: | oct-2019 | Editor: | Elsevier | Citación: | Nanomedicine: Nanotechnology, Biology, and Medicine 21: 102063 (2019) | Resumen: | Endothelial cells are essential to tumor vascularization and impairing their activity can potentially limit tumor growth. Since polyethylenimine (PEI)-coated superparamagnetic iron oxide nanoparticles (SPIONs) are bioactive nanosystems that modulate inflammatory macrophage responses and limit tumor cell invasion, we evaluated their effects on endothelial cell angiogenesis. PEI-SPION triggered proinflammatory gene profiles in a murine endothelial cell line and in primary human umbilical cord vein endothelial cells (HUVECs). These nanoparticles impaired endothelial cell migration and inhibited HUVEC tube formation. Magnetically tumor-targeted PEI-SPIONs reduced tumor vessel numbers and promoted intratumor macrophage infiltration in a tumor xenograft model. PEI-SPION treatment impaired M2 macrophage-promoted tube formation and affected HUVEC cytoskeleton by limiting Src and Cortactin activation. These mechanisms could contribute to PEI-SPION in vitro and in vivo antiangiogenic potential. These data confirm that PEI-SPION administration and application of a localized magnetic field could offer an affordable anti-angiogenic anti-tumoral targeted treatment that would complement other therapies. | Versión del editor: | http://dx.doi.org/10.1016/j.nano.2019.102063 | URI: | http://hdl.handle.net/10261/240972 | DOI: | 10.1016/j.nano.2019.102063 | Identificadores: | doi: 10.1016/j.nano.2019.102063 issn: 1549-9634 |
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