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http://hdl.handle.net/10261/240972
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Mulens-Arias, Vladimir | - |
dc.contributor.author | Rojas, José M. | - |
dc.contributor.author | Sanz-Ortega, Laura | - |
dc.contributor.author | Portilla, Yadileiny | - |
dc.contributor.author | Pérez-Yagüe, Sonia | - |
dc.contributor.author | Barber, Domingo F. | - |
dc.date.accessioned | 2021-05-17T11:30:12Z | - |
dc.date.available | 2021-05-17T11:30:12Z | - |
dc.date.issued | 2019-10 | - |
dc.identifier | doi: 10.1016/j.nano.2019.102063 | - |
dc.identifier | issn: 1549-9634 | - |
dc.identifier.citation | Nanomedicine: Nanotechnology, Biology, and Medicine 21: 102063 (2019) | - |
dc.identifier.uri | http://hdl.handle.net/10261/240972 | - |
dc.description.abstract | Endothelial cells are essential to tumor vascularization and impairing their activity can potentially limit tumor growth. Since polyethylenimine (PEI)-coated superparamagnetic iron oxide nanoparticles (SPIONs) are bioactive nanosystems that modulate inflammatory macrophage responses and limit tumor cell invasion, we evaluated their effects on endothelial cell angiogenesis. PEI-SPION triggered proinflammatory gene profiles in a murine endothelial cell line and in primary human umbilical cord vein endothelial cells (HUVECs). These nanoparticles impaired endothelial cell migration and inhibited HUVEC tube formation. Magnetically tumor-targeted PEI-SPIONs reduced tumor vessel numbers and promoted intratumor macrophage infiltration in a tumor xenograft model. PEI-SPION treatment impaired M2 macrophage-promoted tube formation and affected HUVEC cytoskeleton by limiting Src and Cortactin activation. These mechanisms could contribute to PEI-SPION in vitro and in vivo antiangiogenic potential. These data confirm that PEI-SPION administration and application of a localized magnetic field could offer an affordable anti-angiogenic anti-tumoral targeted treatment that would complement other therapies. | - |
dc.description.sponsorship | LSO and YP receive predoctoral FPU grants (FPU13/05037 and FPU15/06170 respectively) from the Spanish Ministry of Economy and Competitiveness, VMA was a PhD fellow of the La Caixa Foundation International Fellowship Programme (La Caixa/CNB), JMR was supported by a JAEdoc grant co-financed by the CSIC and the European Social Fund. This work was supported in part by grants from the Spanish Ministry of Economy and Competitiveness (SAF-2014-54057-R and SAF-2017-82223-R to DFB). | - |
dc.language | eng | - |
dc.publisher | Elsevier | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF-2014-54057-R | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF-2017-82223-R | - |
dc.rights | closedAccess | - |
dc.subject | Endothelial cells | - |
dc.subject | PEI-coated SPION | - |
dc.subject | Magnetic targeting | - |
dc.subject | Macrophage | - |
dc.subject | Tube formation | - |
dc.subject | Tumor angiogenesis | - |
dc.title | Polyethylenimine-coated superparamagnetic iron oxide nanoparticles impair in vitro and in vivo angiogenesis | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1016/j.nano.2019.102063 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.nano.2019.102063 | - |
dc.date.updated | 2021-05-17T11:30:12Z | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Fundación la Caixa | - |
dc.contributor.funder | European Commission | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.openairetype | artículo | - |
Aparece en las colecciones: | (CNB) Artículos |
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