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Título: | Benign juvenile idiopathic epilepsy in captive Iberian lynx (Lynx pardinus) in the ex situ conservation program (2005–2019) |
Autor: | Minguez, Juan J.; El Bouyafrour, Yasmin; Godoy, José A. CSIC ORCID CVN ; Rivas, Antonio; Fernández, Jesús CSIC ORCID; Asensio, Victoria; Serra, Rodrigo; Pérez-Aspa. María J.; Lorenzo, Valentina | Palabras clave: | Feline Wild cats Lynx Seizure Idiophatic epilepsy Juvenile epilepsy Benign epilepsy |
Fecha de publicación: | 2021 | Editor: | BioMed Central | Citación: | BMC Veterinary Research, 17: 165 (2021) | Resumen: | Background Benign juvenile idiopathic epilepsy has been described in humans but rarely in animals. The objectives of the study were to describe the clinical signs, clinical data, imaging findings, genetic examinations, treatment, long-term outcome and prognosis in Iberian lynx with juvenile epilepsy. Medical records, video recordings and diagnostic data from 2005 to 2019 were reviewed. Results Twenty lynx cubs with early onset of epileptic seizures (ES) from the conservation program were included. The average age at seizure onset was 75 days. Isolated and cluster ES were recorded. Focal ES, focal ES evolving into generalized ES with a stereotypical pattern and generalized ES were observed. All the cubs were normal between episodes, had a normal neurological examination and unremarkable investigations. Phenobarbital was used as a first line antiepileptic drug (AED). ES halted 10 days (0–34) after starting treatment in eight out of twenty cubs (40%). Treatment was discontinued in this group after a mean of 578 days and no further ES were reported (mean follow-up longer than 5 years). Eleven animals (55%) continued on AED treatment for a mean of 1306 days (70–3466). An adult-onset was observed for one lynx (5%). Polytherapy was necessary in seven lynxes (35%). The inheritance pattern observed was compatible with an autosomal recessive condition. Based on this assumption, mating between two identified carriers has been avoided since 2012, which may have contributed to the subsequent decrease in prevalence, with no further cases detected in 2018 and 2019. Conclusions Lynx pardinus may have an early onset self-limiting ES syndrome characteristic of benign juvenile idiopathic epilepsy. Information obtained from this study strongly suggests a genetic basis for the here presented epilepsy | Versión del editor: | https://doi.org/10.1186/s12917-021-02868-z | URI: | http://hdl.handle.net/10261/239373 | DOI: | 10.1186/s12917-021-02868-z |
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