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Título: | Impact of dual-chamber pacing with closed loop stimulation on quality of life in patients with recurrent reflex vasovagal syncope: results of the SPAIN study |
Autor: | Barón Esquivias, G. CSIC ORCID; Moya-Mitjans, Angel; Martinez-Alday, Jesús; Ruiz-Granell, Ricardo; Lacunza-Ruiz, Javier; Garcia-Civera, Roberto; Gutiérrez-Carretero, Encarnación CSIC ORCID; Romero-Garrido, Rafael; Morillo, Carlos A. | Palabras clave: | Closed loop stimulation Quality of life SF-36 Vasovagal syncope |
Fecha de publicación: | feb-2020 | Editor: | Oxford University Press European Society of Cardiology |
Citación: | Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 22(2): 314-319 (2020) | Resumen: | [Aims]: Reflex vasovagal syncope (VVS) is the most common cause of syncope and patients with recurrent episodes may severely impair quality of life (QoL). This pre-specified analysis evaluated whether the clinically significant reduction in syncope burden demonstrated by dual-chamber pacing with closed loop stimulation (DDD-CLS) reported in the SPAIN trial translates into improved QoL. [Methods and results]: Patients aged ≥40 years with ≥5 VVS episodes and cardioinhibitory response induced by head-up tilt testing were included. Patients were randomized 1:1 to active DDD-CLS pacing algorithm for 12 months followed by sham DDI mode for the remaining 12 months (Group A) or vice versa (Group B). QoL was assessed using the Short Form-36 (SF-36) health survey, Physical Component Score (PCS), and Mental Component Score (MCS) before randomization (baseline) and at 12- and 24-month follow-up. Fifty-four patients were enrolled from 11 participating centres. No significant carryover effect was detected for any variable, and the only period effect was observed in the vitality subdomain (P = 0.033). Mean SF-36 scores were higher in the DDD-CLS group vs. the DDI group for the eight subdomains and significantly different in physical role, bodily pain, and vitality (P < 0.05). The analysis of component summary scores indicated that DDD-CLS benefited both mental and physical components with significant differences in PCS when compared with the DDI group. [Conclusion]: Dual-chamber pacing with closed loop stimulation determined a significant and clinically relevant improvement in QoL across both mental and physical components in patients with recurrent VVS. |
Versión del editor: | http://dx.doi.org/10.1093/europace/euz294 | URI: | http://hdl.handle.net/10261/238371 | DOI: | 10.1093/europace/euz294 | ISSN: | 1099-5129 | E-ISSN: | 1532-2092 |
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