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http://hdl.handle.net/10261/238371
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dc.contributor.author | Barón Esquivias, G. | - |
dc.contributor.author | Moya-Mitjans, Angel | - |
dc.contributor.author | Martinez-Alday, Jesús | - |
dc.contributor.author | Ruiz-Granell, Ricardo | - |
dc.contributor.author | Lacunza-Ruiz, Javier | - |
dc.contributor.author | Garcia-Civera, Roberto | - |
dc.contributor.author | Gutiérrez-Carretero, Encarnación | - |
dc.contributor.author | Romero-Garrido, Rafael | - |
dc.contributor.author | Morillo, Carlos A. | - |
dc.date.accessioned | 2021-04-15T17:10:04Z | - |
dc.date.available | 2021-04-15T17:10:04Z | - |
dc.date.issued | 2020-02 | - |
dc.identifier.citation | Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 22(2): 314-319 (2020) | - |
dc.identifier.issn | 1099-5129 | - |
dc.identifier.uri | http://hdl.handle.net/10261/238371 | - |
dc.description.abstract | [Aims]: Reflex vasovagal syncope (VVS) is the most common cause of syncope and patients with recurrent episodes may severely impair quality of life (QoL). This pre-specified analysis evaluated whether the clinically significant reduction in syncope burden demonstrated by dual-chamber pacing with closed loop stimulation (DDD-CLS) reported in the SPAIN trial translates into improved QoL. | - |
dc.description.abstract | [Methods and results]: Patients aged ≥40 years with ≥5 VVS episodes and cardioinhibitory response induced by head-up tilt testing were included. Patients were randomized 1:1 to active DDD-CLS pacing algorithm for 12 months followed by sham DDI mode for the remaining 12 months (Group A) or vice versa (Group B). QoL was assessed using the Short Form-36 (SF-36) health survey, Physical Component Score (PCS), and Mental Component Score (MCS) before randomization (baseline) and at 12- and 24-month follow-up. Fifty-four patients were enrolled from 11 participating centres. No significant carryover effect was detected for any variable, and the only period effect was observed in the vitality subdomain (P = 0.033). Mean SF-36 scores were higher in the DDD-CLS group vs. the DDI group for the eight subdomains and significantly different in physical role, bodily pain, and vitality (P < 0.05). The analysis of component summary scores indicated that DDD-CLS benefited both mental and physical components with significant differences in PCS when compared with the DDI group. | - |
dc.description.abstract | [Conclusion]: Dual-chamber pacing with closed loop stimulation determined a significant and clinically relevant improvement in QoL across both mental and physical components in patients with recurrent VVS. | - |
dc.description.sponsorship | This work was supported by the Research Agency of the Spanish Society of Cardiology. The trial was designed, sponsored, and conducted by the syncope working group and the Research Agency of the Spanish Society of Cardiology. The Research Agency of the Spanish Society of Cardiology received an unrestricted research grant from BIOTRONIK Spain. Medical Writing services were supported by BIOTRONIK SE & Co. KG (Berlin, Germany). | - |
dc.language | eng | - |
dc.publisher | Oxford University Press | - |
dc.publisher | European Society of Cardiology | - |
dc.rights | closedAccess | - |
dc.subject | Closed loop stimulation | - |
dc.subject | Quality of life | - |
dc.subject | SF-36 | - |
dc.subject | Vasovagal syncope | - |
dc.title | Impact of dual-chamber pacing with closed loop stimulation on quality of life in patients with recurrent reflex vasovagal syncope: results of the SPAIN study | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1093/europace/euz294 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1093/europace/euz294 | - |
dc.identifier.e-issn | 1532-2092 | - |
dc.date.updated | 2021-04-15T17:10:04Z | - |
dc.contributor.funder | Sociedad Española de Cardiología | - |
dc.contributor.funder | Biotronik | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100005035 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100009664 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
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