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http://hdl.handle.net/10261/226112
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dc.contributor.author | Castellanos-Moreira, Raul | es_ES |
dc.contributor.author | Rodriguez-García, Sebastian C. | es_ES |
dc.contributor.author | Cabrero-Villalba, Sonia | es_ES |
dc.contributor.author | Gómara Elena, María José | es_ES |
dc.contributor.author | Salvador, Georgina | es_ES |
dc.contributor.author | Ruiz-Esquide, Virginia | es_ES |
dc.contributor.author | Ramírez, Julio | es_ES |
dc.contributor.author | Inciarte-Mundo, José | es_ES |
dc.contributor.author | Morlà, Rosa | es_ES |
dc.contributor.author | García-Moreno, Cristina | es_ES |
dc.contributor.author | Cuervo, Andrea | es_ES |
dc.contributor.author | Gómez-Puerta, José A. | es_ES |
dc.contributor.author | Cañete, Juan D. | es_ES |
dc.contributor.author | Haro Villar, Isabel | es_ES |
dc.contributor.author | Sanmartí, Raimon | es_ES |
dc.date.accessioned | 2021-01-07T09:39:30Z | - |
dc.date.available | 2021-01-07T09:39:30Z | - |
dc.date.issued | 2020-12-10 | - |
dc.identifier.citation | Therapeutic Advances in Musculoskeletal Disease 12: 1-10 (2020) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10261/226112 | - |
dc.description.abstract | [Background]: A restricted response against citrullinated peptides/proteins, with less isotype usage, has been found in palindromic rheumatism (PR) in comparison with rheumatoid arthritis (RA). We hypothesized that this different antibody response may be observed for other post-translational modified proteins. We compared the prevalence and isotype usage of two specificities of anti-carbamylated peptide/protein antibodies (Anti-CarP) in patients with PR and RA. | es_ES |
dc.description.abstract | [Methods]: Cross-sectional study including 54 patients with pure PR and 53 patients with RA, matched by sex, age, disease duration and ACPA. Anti-CarP specificities were determined by home-made enzyme-linked immunosorbent assay tests using a synthetic chimeric fibrin/filaggrin homocitrullinated peptide (CFFHP) and fetal calf serum (FCS) homocitrullinated protein as antigens. IgG, IgA and IgM isotypes were measured. | - |
dc.description.abstract | [Results]: Anti-CarP were positive (CFFHP or FCS) in 24% and 64% of patients with PR and RA, respectively (p < 0.005). All Anti-CarP isotype proportions were significantly lower in PR than in RA: Anti-CarP-IgG (24% versus 51%), Anti-CarP-IgA (7% versus 34%) and Anti-CarP-IgM (7% versus 36%). Mean titers of Anti-CarP isotypes were also lower in PR. In Anti-CarP positive patients, the isotype distribution differed between PR and RA: IgG Anti-CarP was used in all PR patients and in 79% of RA patients. By contrast, a significantly lower isotype usage of both IgA (31% versus 53%) and IgM (31% versus 56%) was observed in PR patients. No significant differences in clinical or demographic characteristics were observed according to Anti-CarP status in PR patients, except for a higher prevalence of ACPA and higher mean titers of ACPA and rheumatoid factor in Anti-CarP positive patients. | - |
dc.description.abstract | [Conclusion]: Anti-CarP are found in patients with PR but in a lower proportion and with a different isotype usage from in RA, suggesting a distinct B cell response to homocitrullinated antigens in PR. | - |
dc.description.sponsorship | The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by the Hospital Clinic of Barcelona, Research, Innovation and Education Department (Grant # 37933 to RC) and the Spanish Ministry of Economy, Industry and Competitiveness and the European Regional Development Fund (Grant # RTI2018-094120-B-I00 to IH). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Sage Publications | es_ES |
dc.relation | MICIU/ICTI2017-2020/RTI2018-094120-B-I00 | es_ES |
dc.relation | RTI2018-094120-B-I00/AEI/10.13039/501100011033 | - |
dc.relation.isversionof | Publisher's version | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | ACPA | es_ES |
dc.subject | Anti-CarP | es_ES |
dc.subject | B cells | es_ES |
dc.subject | Autoantibodies | es_ES |
dc.subject | Palindromic rheumatism | es_ES |
dc.subject | Rheumatoid arthritis | es_ES |
dc.title | Anti-carbamylated protein antibody isotype pattern differs between palindromic rheumatism and rheumatoid arthritis | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1177/1759720X20978139 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1177/1759720X20978139 | es_ES |
dc.identifier.e-issn | 1759-7218 | - |
dc.rights.license | http://creativecommons.org/licenses/by-nc/4.0/ | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.pmid | 33354232 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
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1759720x20978139.pdf | Artículo principal | 752,44 kB | Adobe PDF | Visualizar/Abrir |
10.1177-1759720X20978139-table1-1759720X20978139.pdf | Material suplementario | 284,85 kB | Adobe PDF | Visualizar/Abrir |
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