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Título: | Association between bat vitamin D receptor 30 haplotypes and vitamin D levels at baseline and a lower response after increased vitamin D supplementation and exposure to sunlight |
Autor: | Pérez-Alonso, María; Briongos, Laisa-Socorrro; Ruiz-Mambrilla, Marta; Velasco, Eladio CSIC ORCID ; Olmos, José-Manuel; Luis-Román, Daniel A. de; Dueñas-Laita, Antonio; Pérez-Castrillón, José Luis | Palabras clave: | Vitamin D receptor Haplotypes ApaI Genotypes BsmI TaqI |
Fecha de publicación: | 2020 | Editor: | Hogrefe & Huber Publishers | Citación: | International Journal for Vitamin and Nutrition Research 90(3-4): 290-294 (2020) | Resumen: | [Objective]: The aim of this study was to evaluate the relationship between vitamin D levels at baseline and after 12 weeks of supplementation/exposure to sunlight and VDR genotypes (BsmI, TaqI and ApaI) and haplotypes in a homogeneous population of postmenopausal women. [Methods]: We made a prospective study in which 151 women were randomized to two groups: One with 1000 mg of calcium and 800 IU vitamin D supplementation (102 women) and a placebo group with neither calcium or vitamin D supplementation (49 women). The follow-up was from May to September 2012.Vitamin D was determined by chemiluminescent immunoassay. Genotypes were determined using the Sequenomi Plexplatform and haplotypes using PHASE software. [Results]: Baseline (25 ± 10 ng/mlvs.23 ± 9 ng/ml, p > 0.05) and 12-week (32 ± 8 ng/mlvs.29 ± 10 ng/ml, p > 0.05) vitamin D levels were similar between the two groups. The genetic study was made in the total population. There were no differences in baseline and final levels of vitamin D in terms of genotypes and haplotypes, except for the Bat haplotype, whose baseline values were lower (25OHD: 21 ± 10 ng/mlvs. 21 ± 10 ng/ml, p = 0.038). The rate of nonresponders in this group was 15 % (p = 0.001), compared with 9 %, 2 % and 3 % in the other groups. [Conclusions]: The Bat haplotype was associated with lower baseline levels of vitamin D and a worse response to supplementation and, therefore, may be a risk factor for vitamin D deficiency. |
Versión del editor: | https://doi.org/10.1024/0300-9831/a000534 | URI: | http://hdl.handle.net/10261/223137 | DOI: | 10.1024/0300-9831/a000534 | ISSN: | 0300-9831 | E-ISSN: | 1664-2821 |
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