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Título: | Dietary Compounds to Reduce in Vivo Inorganic Arsenic Bioavailability |
Autor: | Clemente, María Jesús; Cimbalo, Alessandra; Chiocchetti, Gabriela M.; Devesa, Vicenta CSIC ORCID ; Vélez, Dinoraz CSIC ORCID | Palabras clave: | Inorganic arsenic Bioavailability Tissue accumulation Fecal excretion Glutathione Iron salts Tannic acid |
Fecha de publicación: | 2019 | Editor: | ACS Publications | Citación: | Journal of agricultural and food chemistry 67: 9032- 9038 (2019) | Resumen: | It is estimated that approximately 200 million people are exposed to arsenic levels above the World Health Organization provisional guideline value, and various agencies have indicated the need to reduce this exposure. In view of the difficulty of removing arsenic from water and food, one alternative is to reduce its bioavailability (the amount that reaches the systemic circulation after ingestion). In this study, dietary components [glutathione, tannic acid, and Fe(III)] were used to achieve this goal. As(III) or As(V) (1 mg/kg body weight) was administered daily to BALB/c mice, along with the dietary components, for 15 days. The results confirm the efficacy of Fe(III) and glutathione as reducers of arsenic bioavailability and tissue accumulation. Also, these treatments did not result in reductions of Ca, K, P, and Fe contents in the liver. These data suggest that use of these two compounds could be part of valid strategies for reducing inorganic arsenic exposure in chronically exposed populations. | Versión del editor: | http://dx.doi.org/10.1021/acs.jafc.9b03372 | URI: | http://hdl.handle.net/10261/201468 | DOI: | 10.1021/acs.jafc.9b03372 | Identificadores: | doi: 10.1021/acs.jafc.9b03372 issn: 1520-5118 |
Aparece en las colecciones: | (IATA) Artículos |
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