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http://hdl.handle.net/10261/195461
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Navarro-Tapia, Elisabet | - |
dc.contributor.author | Querol, Amparo | - |
dc.contributor.author | Pérez-Torrado, Roberto | - |
dc.date.accessioned | 2019-11-25T11:41:59Z | - |
dc.date.available | 2019-11-25T11:41:59Z | - |
dc.date.issued | 2018 | - |
dc.identifier | doi: 10.1111/1751-7915.13032 | - |
dc.identifier | issn: 1751-7915 | - |
dc.identifier.citation | Microbial Biotechnology 11: 465- 475 (2018) | - |
dc.identifier.uri | http://hdl.handle.net/10261/195461 | - |
dc.description.abstract | The toxic effect of ethanol is one of the most important handicaps for many biotechnological applications of yeasts, such as bioethanol production. Elucidation of ethanol stress response will help to improve yeast performance in biotechnological processes. In the yeast Saccharomyces cerevisiae, ethanol stress has been recently described as an activator of the unfolded protein response (UPR), a conserved intracellular signalling pathway that regulates the transcription of ER homoeostasis-related genes. However, the signal and activation mechanism has not yet been unravelled. Here, we studied UPR's activation after ethanol stress and observed the upregulation of the key target genes, like INO1, involved in lipid metabolism. We found that inositol content influenced UPR activation after ethanol stress and we observed significant changes in lipid composition, which correlate with a major membrane fluidity alteration by this amphipathic molecule. Then, we explored the hypothesis that membrane fluidity changes cause UPR activation upon ethanol stress by studying UPR response against fluidification or rigidification agents and by studying a mutant, erg2, with altered membrane fluidity. The results suggest that the membrane fluidification effects of ethanol and other agents are the signal for UPR activation, a mechanism that has been proposed in higher eukaryotes. | - |
dc.description.sponsorship | E. Navarro‐Tapia was supported by an FPU grant from the Ministerio de Educación y Ciencia (ref. AP2009‐0787). This work was supported by grants AGL2012‐39937‐C02‐01 and AGL2015‐67504‐C3‐1‐R from the Spanish Government and FEDER and by grant PROMETEO (Project PROMETEO/2009/019) from the Generalitat Valenciana to A. Querol. | - |
dc.publisher | John Wiley & Sons | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2015‐67504‐C3‐1‐R | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.title | Membrane fluidification by ethanol stress activates unfolded protein response in yeasts | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1111/1751-7915.13032 | - |
dc.date.updated | 2019-11-25T11:41:59Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.rights.license | http://creativecommons.org/licenses/by/4.0/ | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Generalitat Valenciana | - |
dc.contributor.funder | European Commission | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003359 | es_ES |
dc.identifier.pmid | 29469174 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.openairetype | artículo | - |
item.fulltext | With Fulltext | - |
Aparece en las colecciones: | (IATA) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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MicBiol2018-Navarro.pdf | 1,09 MB | Adobe PDF | Visualizar/Abrir | |
MicrobBiotecnol2018postprint.pdf | 1,46 MB | Adobe PDF | Visualizar/Abrir |
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