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Título: | Pru p 3‐Epitope‐based sublingual immunotherapy in a murine model for the treatment of peach allergy |
Autor: | Rodriguez, Maria, J.; Mascaraque, Ainhoa CSIC; Ramos, Javier CSIC ORCID ; Torres, Maria J.; Perkins, James R.; Gómez, Francisca; Garrido-Arandia, María; Cubells baeza, Nuria; Andreu, David; Díaz-Perales, Araceli; Rojo, Francisco Javier ; Mayorga, Cristobalina | Palabras clave: | Anaphylaxis Food‐allergy Lipid transfer protein Mouse model Sublingual immunotherapy |
Fecha de publicación: | 6-jun-2017 | Editor: | John Wiley & Sons | Citación: | Molecular Nutrition and Food Research 61(10): 1700110 (2017) | Resumen: | [Scope] Food‐specific immunotherapy (SIT) is a promising treatment for lipid transfer protein (LTP)‐syndrome. We propose a novel sublingual‐SIT (SLIT) that combines a Pru p 3 T‐cell peptide and an oligodeoxyribonucleotide (ODN) with CpG motifs (ODN‐CpG) as adjuvants to induce a specific Th1/Treg response. [Methods and results] LTP‐peach allergic mice were treated sublingually with a combination of a CpG sequence and mono‐ or tetravalent systems including a Pru p 3 peptide, D1(Prup3) or D4(Prup3). Mice were challenged intraperitoneally with Pru p 3 one or three weeks after SLIT and tolerance was assessed. Mice treated with D1(Prup3)+CpG were protected from anaphylaxis after Pru p 3 challenge. They showed no change in body temperature, lower levels of Pru p 3‐specific IgE and IgG1 antibodies and higher levels of sIgG2a compared to the untreated group. They had fewer IgE and IgG1 secreting cells and more sIgG2a secreting cells. Moreover, a significantly lower number of Pru p 3‐specific CD4+T cells and a higher number of Treg cells were found, alongside a Th1 cytokine pattern. These changes were maintained for three weeks after stopping treatment. [Conclusion] D1Prup3+CpG represents a promising SIT for food allergy. It is easily synthesized and induces protection from anaphylaxis to Pru p 3 that is maintained for at least three weeks. |
Versión del editor: | https://doi.org/10.1002/mnfr.201700110 | URI: | http://hdl.handle.net/10261/190522 | DOI: | 10.1002/mnfr.201700110 | ISSN: | 1613-4125 | E-ISSN: | 1613-4133 |
Aparece en las colecciones: | (IIQ) Artículos |
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