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Título: | Synthesis and Neuroprotective Properties of N-Substituted C-Dialkoxyphosphorylated Nitrones |
Autor: | Piotrowska, D. G.; Mediavilla, L.; Cuarental, L.; Głowacka, Iwona E.; Marco-Contelles, José CSIC ORCID; Hadjipavlou-Litina, D.; López-Muñoz, Francisco; Oset-Gasque, María Jesús | Fecha de publicación: | 2019 | Editor: | American Chemical Society | Citación: | ACS Omega 4: 8581-8587 (2019) | Resumen: | Herein, we report the synthesis and neuroprotective power of some N-substituted C-(dialkoxy)phosphorylated nitrones 4a-g, by studying their ability to increase the cell viability, as well as their capacity to reduce necrosis and apoptosis. We have identified (Z)-N-tert-butyl-1-(diethoxyphosphoryl)methanimine oxide (4e) as the most potent, nontoxic, and neuroprotective agent, with a high activity against neuronal necrotic cell death, a result that correlates very well with its great capacity for the inhibition of the superoxide production (72%), as well as with the inhibition of lipid peroxidation (62%), and the 5-lipoxygenase activity (45%) at 100 μM concentrations. Thus, nitrone 4e could be a convenient promising compound for further investigation. | Versión del editor: | http://dx.doi.org/10.1021/acsomega.9b00189 | URI: | http://hdl.handle.net/10261/184876 | DOI: | 10.1021/acsomega.9b00189 | Identificadores: | doi: 10.1021/acsomega.9b00189 issn: 2470-1343 |
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