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http://hdl.handle.net/10261/184876
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dc.contributor.author | Piotrowska, D. G. | - |
dc.contributor.author | Mediavilla, L. | - |
dc.contributor.author | Cuarental, L. | - |
dc.contributor.author | Głowacka, Iwona E. | - |
dc.contributor.author | Marco-Contelles, José | - |
dc.contributor.author | Hadjipavlou-Litina, D. | - |
dc.contributor.author | López-Muñoz, Francisco | - |
dc.contributor.author | Oset-Gasque, María Jesús | - |
dc.date.accessioned | 2019-06-26T10:33:47Z | - |
dc.date.available | 2019-06-26T10:33:47Z | - |
dc.date.issued | 2019 | - |
dc.identifier | doi: 10.1021/acsomega.9b00189 | - |
dc.identifier | issn: 2470-1343 | - |
dc.identifier.citation | ACS Omega 4: 8581-8587 (2019) | - |
dc.identifier.uri | http://hdl.handle.net/10261/184876 | - |
dc.description.abstract | Herein, we report the synthesis and neuroprotective power of some N-substituted C-(dialkoxy)phosphorylated nitrones 4a-g, by studying their ability to increase the cell viability, as well as their capacity to reduce necrosis and apoptosis. We have identified (Z)-N-tert-butyl-1-(diethoxyphosphoryl)methanimine oxide (4e) as the most potent, nontoxic, and neuroprotective agent, with a high activity against neuronal necrotic cell death, a result that correlates very well with its great capacity for the inhibition of the superoxide production (72%), as well as with the inhibition of lipid peroxidation (62%), and the 5-lipoxygenase activity (45%) at 100 μM concentrations. Thus, nitrone 4e could be a convenient promising compound for further investigation. | - |
dc.description.sponsorship | The synthetic part of the project was supported by the National Science Centre (grant UMO-2015/17/B/ST5/ 00076). D.H.-L. gratefully acknowledges Dr A. Leo and Biobyte Corp., 201 West 4th Street, Suite 204, Claremont, CA 91711, for free access to the C-QSAR program. J.M.-C. and M.J.O.-G. thank MINECO (Government of Spain) (SAF2015- 65586-R) and Universidad Camilo José Cela (NitroStroke project, 2015-12) for support. | - |
dc.publisher | American Chemical Society | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2015-65586-R | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.title | Synthesis and Neuroprotective Properties of N-Substituted C-Dialkoxyphosphorylated Nitrones | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1021/acsomega.9b00189 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1021/acsomega.9b00189 | - |
dc.date.updated | 2019-06-26T10:33:47Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Universidad Camilo José Cela | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100008742 | es_ES |
dc.identifier.pmid | 31459948 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.openairetype | artículo | - |
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