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http://hdl.handle.net/10261/181442
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Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Corredor, Miriam | es_ES |
dc.contributor.author | Carbajo, Daniel | es_ES |
dc.contributor.author | Domingo, Cecilia | es_ES |
dc.contributor.author | Pérez, Yolanda | es_ES |
dc.contributor.author | Bujons, Jordi | es_ES |
dc.contributor.author | Messeguer, Àngel | es_ES |
dc.contributor.author | Alfonso, Ignacio | es_ES |
dc.date.accessioned | 2019-05-15T07:52:45Z | - |
dc.date.available | 2019-05-15T07:52:45Z | - |
dc.date.issued | 2018-09-10 | - |
dc.identifier.citation | Angewandte Chemie - International Edition 57 (37): 11973-11977 (2018) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10261/181442 | - |
dc.description.abstract | Despite heparin being the most widely used macromolecular drug, the design of small-molecule ligands to modulate its effects has been hampered by the structural properties of this polyanionic polysaccharide. Now a dynamic covalent selection approach is used to identify a new ligand for heparin, assembled from extremely simple building blocks. The amplified molecule strongly binds to heparin (K D in the low μm range, ITC) by a combination of electrostatic, hydrogen bonding, and CH–π interactions as shown by NMR and molecular modeling. Moreover, this ligand reverts the inhibitory effect of heparin within an enzymatic cascade reaction related to blood coagulation. This study demonstrates the power of dynamic covalent chemistry for the discovery of new modulators of biologically relevant glycosaminoglycans. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim | es_ES |
dc.description.sponsorship | Financial Support from the Spanish Ministry of Economy, Industry and Competitiveness (MINECO/FEDER, CTQ2015-70117-R) and AGAUR (2017 SGR 208) is gratefully acknowledged. The 500 MHz spectrometer and cryoprobe in the IQAC NMR facility were funded by the CSIC13-4E2076 MINECO-FEDER grant. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley-Blackwell | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2015-70117-R | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CSIC13-4E2076 | es_ES |
dc.relation.isversionof | Postprint | es_ES |
dc.rights | openAccess | en_EN |
dc.subject | Dynamics | es_ES |
dc.subject | Dynamic covalent chemistry | es_ES |
dc.subject | Glycosaminoglycans | es_ES |
dc.subject | Heparin | es_ES |
dc.subject | Molecular recognition | es_ES |
dc.subject | Supramolecular chemistry | es_ES |
dc.title | Dynamic Covalent Identification of an Efficient Heparin Ligand | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1002/anie.201806770 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1002/anie.201806770 | es_ES |
dc.embargo.terms | 2019-09-10 | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.contributor.orcid | Bujons, Jordi [0000-0003-2944-2905] | es_ES |
dc.contributor.orcid | Messeguer, Àngel [0000-0002-8358-9425] | es_ES |
dc.contributor.orcid | Alfonso, Ignacio [0000-0003-0678-0362] | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.openairetype | artículo | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
Aparece en las colecciones: | (IQAC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Dynamic covalent identification of an efficient heparin ligand.pdf | 6,61 MB | Adobe PDF | Visualizar/Abrir | |
anie201806770-sup-0001-misc_information.pdf | Material suplementario | 5,75 MB | Adobe PDF | Visualizar/Abrir |
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