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http://hdl.handle.net/10261/179976
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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Carbajo, Daniel | es_ES |
dc.contributor.author | Fransen, Peter Paul K.H. | es_ES |
dc.contributor.author | El-Faham, Ayman | es_ES |
dc.contributor.author | Royo, Miriam | es_ES |
dc.contributor.author | Albericio, Fernando | es_ES |
dc.date.accessioned | 2019-04-12T07:31:42Z | - |
dc.date.available | 2019-04-12T07:31:42Z | - |
dc.date.issued | 2019-03-14 | - |
dc.identifier.citation | Organic Letters 21 (7): 2459-2463 (2019) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10261/179976 | - |
dc.description.abstract | A handle for the protection of the C-terminus of peptides after cleaving with low concentration of trifluoroacetic acid (2-4%) is reported. The handle prevents polymerization reactions in the convergent condensation of peptidic fragments. Moreover, it is traceless, being removed during the final deprotection step of the peptide synthesis. This cheap and convenient handle is easily attached to the solid support, causing no disturbance to peptide elongation and thus proving to be useful in the convergent synthesis of long peptides. © 2019 American Chemical Society. | es_ES |
dc.description.sponsorship | This work was funded in part by the following: Lonza AG (Wisp, Switzerland), the Spanish Ministry of Economy, Industry, and Competitiveness (MINECO) (CTQ2015-67870-P & RTC-2014-2207-1), CIBER-BBN, the Generalitat de Catalunya (2017 SGR 1439) (Spain), and the International Scientific Partnership Program ISPP at King Saud University (ISPP# 0061) (Saudi Arabia). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Chemical Society | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2015-67870-P | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/RTC-2014-2207-1 | es_ES |
dc.relation.isversionof | Postprint | es_ES |
dc.rights | openAccess | en_EN |
dc.subject | Synthesis of Liraglutide | es_ES |
dc.subject | Peptides | es_ES |
dc.subject | Fragment condensation | es_ES |
dc.title | Pseudo-Wang Handle for the Preparation of Fully Protected Peptides. Synthesis of Liraglutide by Fragment Condensation | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1021/acs.orglett.9b00813 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://pubs.acs.org/doi/abs/10.1021/acs.orglett.9b00813?af=R | es_ES |
dc.embargo.terms | 2020-03-14 | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.contributor.orcid | Royo, Miriam [0000-0001-5292-0819] | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.openairetype | artículo | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
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Pseudo-Wang Handle for the Preparation of Fully Protected Peptides.docx | 480,35 kB | Microsoft Word XML | Visualizar/Abrir |
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