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Título: | Prevalent Sequences in the Human Genome Can Form Mini i-Motif Structures at Physiological pH |
Autor: | Mir, Bartomeu CSIC ORCID; Serrano-Chacón, Israel CSIC ORCID; Buitrago, Diana; Orozco, Modesto; Escaja, Núria; González, Carlos CSIC | Fecha de publicación: | 2017 | Editor: | American Chemical Society | Citación: | Journal of the American Chemical Society 139: 13985- 13988 (2017) | Resumen: | We report here the solution structure of several repetitive DNA sequences containing d(TCGTTCCGT) and related repeats. At physiological pH, these sequences fold into i-motif like quadruplexes in which every two repeats a globular structure is stabilized by two hemiprotonated C:C base pairs, flanked by two minor groove tetrads resulting from the association of G:C or G:T base pairs. The interaction between the minor groove tetrads and the nearby C:C base pairs affords a strong stabilization, which results in effective pH values above 7.5. Longer sequences with more than two repeats are able to fold in tandem, forming a rosary bead-like structure. Bioinformatics analysis shows that these sequences are prevalent in the human genome, and are present in development-related genes. | URI: | http://hdl.handle.net/10261/165588 | DOI: | 10.1021/jacs.7b07383 | Identificadores: | doi: 10.1021/jacs.7b07383 issn: 1520-5126 |
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