Please use this identifier to cite or link to this item:
http://hdl.handle.net/10261/144062
Share/Export:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Title: | Analysis by LC/ESI-MS of iophenoxic acid derivatives and evaluation as markers of oral baits to deliver pharmaceuticals to wildlife |
Authors: | Ballesteros, Cristina CSIC; Camarero, Pablo R. CSIC ORCID; Vicente, Joaquín CSIC ORCID ; Gortázar, Christian CSIC ORCID ; Fuente, José de la CSIC ORCID ; Mateo, Rafael CSIC ORCID | Issue Date: | 2010 | Publisher: | Elsevier | Citation: | Journal of chromatography B 878(22): 1997-2002 (2010) | Abstract: | Iophenoxic acid and its derivatives (methyl, ethyl, and propyl) are organic chemicals used as markers in baiting campaigns to deliver vaccines, pharmaceuticals, contraceptives or poisons to wildlife. In this study we develop a method of detection of IPA derivatives by LC/ESI-MS (using butyl-IPA as internal standard) obtaining a limit of detection and quantification in wild boar (Sus scrofa) serum of 0.037 microg/ml and 0.123 microg/ml, respectively. The average recovery of IPA derivatives was 88% at levels >0.2 microg/ml, with coefficients of variation <15%. Wild boars in captivity were orally treated with 5 mg/kg b.w. (three adults) or 15 mg/kg b.w (two piglets and three adults) of methyl-, ethyl- and propyl-IPA and the serum levels of these were monitored during 18 months after dosing. Ethyl- and propyl-IPA were detected up to 18 months after a single oral dose in wild boar, especially at 15 mg/kg. Methyl-IPA was detected until 9 months after dosing. Half-lives of methyl-, ethyl- and propyl-IPA were (mean+/-SD) 41+/-5, 183+/-85 and 165+/-45 days, respectively. One control piglet not exposed to IPA, but housed in the same facility than treated animals showed detectable IPA levels in serum. Piglets born from mothers exposed to marked baits also showed detectable IPA levels in serum. The high persistence of Et- and Pr-IPA must be considered in the field trials, because the presence of the product at low levels in one animal may not reflect a real ingestion of the marked bait. | URI: | http://hdl.handle.net/10261/144062 | DOI: | 10.1016/j.jchromb.2010.05.035 | Identifiers: | doi: 10.1016/j.jchromb.2010.05.035 issn: 1570-0232 |
Appears in Collections: | (IREC) Artículos |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | View/Open |
CORE Recommender
SCOPUSTM
Citations
11
checked on May 2, 2024
WEB OF SCIENCETM
Citations
10
checked on Feb 27, 2024
Page view(s)
353
checked on May 12, 2024
Download(s)
82
checked on May 12, 2024
Google ScholarTM
Check
Altmetric
Altmetric
WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.