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dc.contributor.authorBallesteros, Cristina-
dc.contributor.authorCamarero, Pablo R.-
dc.contributor.authorVicente, Joaquín-
dc.contributor.authorGortázar, Christian-
dc.contributor.authorFuente, José de la-
dc.contributor.authorMateo, Rafael-
dc.identifierdoi: 10.1016/j.jchromb.2010.05.035-
dc.identifierissn: 1570-0232-
dc.identifier.citationJournal of chromatography B 878(22): 1997-2002 (2010)-
dc.description.abstractIophenoxic acid and its derivatives (methyl, ethyl, and propyl) are organic chemicals used as markers in baiting campaigns to deliver vaccines, pharmaceuticals, contraceptives or poisons to wildlife. In this study we develop a method of detection of IPA derivatives by LC/ESI-MS (using butyl-IPA as internal standard) obtaining a limit of detection and quantification in wild boar (Sus scrofa) serum of 0.037 microg/ml and 0.123 microg/ml, respectively. The average recovery of IPA derivatives was 88% at levels >0.2 microg/ml, with coefficients of variation <15%. Wild boars in captivity were orally treated with 5 mg/kg b.w. (three adults) or 15 mg/kg b.w (two piglets and three adults) of methyl-, ethyl- and propyl-IPA and the serum levels of these were monitored during 18 months after dosing. Ethyl- and propyl-IPA were detected up to 18 months after a single oral dose in wild boar, especially at 15 mg/kg. Methyl-IPA was detected until 9 months after dosing. Half-lives of methyl-, ethyl- and propyl-IPA were (mean+/-SD) 41+/-5, 183+/-85 and 165+/-45 days, respectively. One control piglet not exposed to IPA, but housed in the same facility than treated animals showed detectable IPA levels in serum. Piglets born from mothers exposed to marked baits also showed detectable IPA levels in serum. The high persistence of Et- and Pr-IPA must be considered in the field trials, because the presence of the product at low levels in one animal may not reflect a real ingestion of the marked bait.-
dc.description.sponsorshipThis study was supported by grants from the European Union (Project TB-STEP 212414), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA) (Project FAU 2006-00017-C03-01), Consejería de Educación y Ciencia, Junta de Comunidades de Castilla-La Mancha (JCCM) (Project PAI 06-0046-5285), the Grupo Santander and the Fundación Marcelino Botín, Spain.-
dc.titleAnalysis by LC/ESI-MS of iophenoxic acid derivatives and evaluation as markers of oral baits to deliver pharmaceuticals to wildlife-
dc.description.versionPeer Reviewed-
dc.contributor.funderEuropean Commission-
dc.contributor.funderInstituto Nacional de Investigación y Tecnología Agraria y Alimentaria (España)-
dc.contributor.funderJunta de Comunidades de Castilla-La Mancha-
dc.contributor.funderFundación Botín-
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