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Título: | Essential function for the GTPase TC21 in homeostatic antigen receptor signaling |
Autor: | Delgado, Pilar CSIC ORCID; Cubelos, Beatriz CSIC ORCID; Calleja, Enrique; Martínez-Martín, Nuria CSIC ORCID; Ciprés, Ángel; Mérida, Isabel CSIC ORCID ; Bustelo, Xosé R. CSIC ORCID ; Alarcón, Balbino CSIC ORCID | Fecha de publicación: | 28-jun-2009 | Editor: | Nature Publishing Group | Citación: | Nature Immunology (2009), doi: 10.1038/ni.1749 (In press) | Resumen: | T cell antigen receptors (TCRs) and B cell antigen receptors (BCRs) transmit low-grade signals necessary for the survival and maintenance of mature cell pools. We show here that TC21, a small GTPase encoded by Rras2, interacted constitutively with both kinds of receptors. Expression of a dominant negative TC21 mutant in T cells produced a rapid decrease in cell viability, and Rras2-/- mice were lymphopenic, possibly as a result of diminished homeostatic proliferation and impaired T cell and B cell survival. In contrast, TC21 was overexpressed in several human lymphoid malignancies. Finally, the p110 catalytic subunit of phosphatidylinositol-3-OH kinase (PI(3)K) was recruited to the TCR and BCR in a TC21-dependent way. Consequently, we propose TC21 directly links antigen receptors to PI(3)K-mediated survival pathways. | Descripción: | 10 pages, 7 figures.-- Article in press. Supporting information available at: http://www.nature.com/ni/journal/vaop/ncurrent/suppinfo/ni.1749_S1.html |
Versión del editor: | http://dx.doi.org/10.1038/ni.1749 | URI: | http://hdl.handle.net/10261/14086 | DOI: | 10.1038/ni.1749 | ISSN: | 1529-2908 | E-ISSN: | 1529-2916 |
Aparece en las colecciones: | (CBM) Artículos (CNB) Artículos (IBMCC) Artículos |
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