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http://hdl.handle.net/10261/14086
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Delgado, Pilar | - |
dc.contributor.author | Cubelos, Beatriz | - |
dc.contributor.author | Calleja, Enrique | - |
dc.contributor.author | Martínez-Martín, Nuria | - |
dc.contributor.author | Ciprés, Ángel | - |
dc.contributor.author | Mérida, Isabel | - |
dc.contributor.author | Bustelo, Xosé R. | - |
dc.contributor.author | Alarcón, Balbino | - |
dc.date.accessioned | 2009-06-29T16:55:48Z | - |
dc.date.available | 2009-06-29T16:55:48Z | - |
dc.date.issued | 2009-06-28 | - |
dc.identifier.citation | Nature Immunology (2009), doi: 10.1038/ni.1749 (In press) | en_US |
dc.identifier.issn | 1529-2908 | - |
dc.identifier.uri | http://hdl.handle.net/10261/14086 | - |
dc.description | 10 pages, 7 figures.-- Article in press. | en_US |
dc.description | Supporting information available at: http://www.nature.com/ni/journal/vaop/ncurrent/suppinfo/ni.1749_S1.html | - |
dc.description.abstract | T cell antigen receptors (TCRs) and B cell antigen receptors (BCRs) transmit low-grade signals necessary for the survival and maintenance of mature cell pools. We show here that TC21, a small GTPase encoded by Rras2, interacted constitutively with both kinds of receptors. Expression of a dominant negative TC21 mutant in T cells produced a rapid decrease in cell viability, and Rras2-/- mice were lymphopenic, possibly as a result of diminished homeostatic proliferation and impaired T cell and B cell survival. In contrast, TC21 was overexpressed in several human lymphoid malignancies. Finally, the p110 catalytic subunit of phosphatidylinositol-3-OH kinase (PI(3)K) was recruited to the TCR and BCR in a TC21-dependent way. Consequently, we propose TC21 directly links antigen receptors to PI(3)K-mediated survival pathways. | en_US |
dc.description.sponsorship | Supported by the Comisión Interministerial de Ciencia y Tecnología (SAF2006-01391), Comunidad de Madrid (SAL-0159/2006), Redes Temáticas de Investigación Cooperativa en Salud (RD06/0020/1002), the Junta de Ampliación de Estudios-doc 2008 program (B.C.) and Fundación Ramón Areces (to the Centro de Biología Molecular Severo Ochoa). | en_US |
dc.format.extent | 46625 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | en_US |
dc.publisher | Nature Publishing Group | en_US |
dc.rights | closedAccess | en_US |
dc.title | Essential function for the GTPase TC21 in homeostatic antigen receptor signaling | en_US |
dc.type | artículo | en_US |
dc.identifier.doi | 10.1038/ni.1749 | - |
dc.description.peerreviewed | Peer reviewed | en_US |
dc.relation.publisherversion | http://dx.doi.org/10.1038/ni.1749 | en_US |
dc.identifier.e-issn | 1529-2916 | - |
dc.contributor.funder | Comisión Interministerial de Ciencia y Tecnología, CICYT (España) | - |
dc.contributor.funder | Comunidad de Madrid | - |
dc.contributor.funder | Instituto de Salud Carlos III | - |
dc.contributor.funder | Fundación Ramón Areces | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100007273 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100008054 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100012818 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
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