Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/123807
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Insect glycerol transporters evolved by functional co-option and gene replacement |
Autor: | Finn, Roderick N.; Chauvigné, François CSIC ORCID; Stavang, Jon A.; Bellés, Xavier CSIC ORCID ; Cerdà, Joan CSIC ORCID | Fecha de publicación: | jul-2015 | Editor: | Nature Publishing Group | Citación: | Nature Communications 6: 7814 (2015) | Resumen: | Transmembrane glycerol transport is typically facilitated by aquaglyceroporins in Prokaryota and Eukaryota. In holometabolan insects however, aquaglyceroporins are absent, yet several species possess polyol permeable aquaporins. It thus remains unknown how glycerol transport evolved in the Holometabola. By combining phylogenetic and functional studies, here we show that a more efficient form of glycerol transporter related to the water-selective channel AQP4 specifically evolved and multiplied in the insect lineage, resulting in the replacement of the ancestral branch of aquaglyceroporins in holometabolan insects. To recapitulate this evolutionary process, we generate specific mutants in distantly related insect aquaporins and human AQP4 and show that a single mutation in the selectivity filter converted a water-selective channel into a glycerol transporter at the root of the crown clade of hexapod insects. Integration of phanerozoic climate models suggests that these events were associated with the emergence of complete metamorphosis and the unparalleled radiation of insects. © 2015 Macmillan Publishers Limited. All rights reserved | Descripción: | 7 pages, 4 figures, supplementary Information accompanies this paper at http://dx.doi.org/10.1038/ncomms8814 | Versión del editor: | http://dx.doi.org/10.1038/ncomms8814 | URI: | http://hdl.handle.net/10261/123807 | DOI: | 10.1038/ncomms8814 | Identificadores: | doi: 10.1038/ncomms8814 e-issn: 2041-1723 |
Aparece en las colecciones: | (ICM) Artículos (IBE) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Finn_et_al_2015.pdf | 1,33 MB | Adobe PDF | Visualizar/Abrir | |
Finn_et_al_2015_s_1.pdf | 5,88 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
24
checked on 26-abr-2024
SCOPUSTM
Citations
64
checked on 26-abr-2024
WEB OF SCIENCETM
Citations
58
checked on 26-feb-2024
Page view(s)
292
checked on 01-may-2024
Download(s)
323
checked on 01-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.