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Título: | HIV-1 inhibiting capacity of novel forms of presentation of GB virus C peptide domains is enhanced by coordination to gold compounds |
Autor: | Gómara Elena, María José CSIC ORCID; Galatola, Ramona CSIC ORCID; Gutiérrez, Alejandro CSIC; Gimeno, M. Concepción CSIC ORCID; Gatell, José María; Sánchez-Merino, Víctor; Yuste, Eloísa; Haro Villar, Isabel CSIC ORCID | Palabras clave: | Cyclic peptides Cell–cell fusion assays HIV-1 GBV-C Lipopeptides Peptide–gold complexes Multiple antigenic peptides Anti-HIV assays |
Fecha de publicación: | 2014 | Editor: | Bentham Science Publishers | Citación: | Current Medicinal Chemistry 21(2): 238-250 (2014) | Resumen: | Following the report of beneficial effects of co-infection by GB virus C (GBV-C) for HIV-infected patients, we have studied synthetic GBV-C peptides and their relationship with HIV type-1. This paper reports the design and synthesis of new forms of presentation of two peptide inhibitors corresponding to the envelope proteins E1 and E2 of GBV-C, together with a study of their anti-HIV-1 activity. Homogeneous and heterogeneous multiple antigenic peptides (MAPs), lipophilic derivatizations, cyclization and peptide-gold conjugations are the chemical design strategies adopted. Our aim is to enhance the anti-viral potency of the GBV-C peptide domains. Of all the GBV-C peptide derivatives studied, peptide- gold complexes derived from the (22-39) sequence of the GBV-C E1 protein were the most active entry inhibitors. These results support the putative modulation of HIV-1 infection by the GBV-C E1 protein and open new perspectives for the development of novel peptide-derived HIV-1 entry inhibitors. © 2014 Bentham Science Publishers. | URI: | http://hdl.handle.net/10261/111726 | DOI: | 10.2174/09298673113206660276 | Identificadores: | doi: 10.2174/09298673113206660276 issn: 0929-8673 e-issn: 1875-533X |
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