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openAccess2023 JIMD 46-261.pdf.jpgmar-2023Pathogenic variants of the coenzyme A biosynthesis-associated enzyme phosphopantothenoylcysteine decarboxylase cause autosomal-recessive dilated cardiomyopathyBravo-Alonso, Irene; Morin, Matias; Arribas-Carreira, Laura; Álvarez, Mar CSIC ORCID; Padrón-Giner, Consuelo; Soletto, Lucia; Santolaria, Carlos; Ramón-Maiques, Santiago CSIC ORCID ; Ugarte, Magdalena CSIC ; Rodríguez-Pombo, Pilar CSIC ORCID; Ariño, Joaquín; Moreno-Pelayo, Miguel Ángel; Pérez, Belén CSIC ORCIDartículo
openAccess2022 Comput Struct Biotechnol J 20-6182.pdf.jpg11-nov-2022Phosphorylation of T897 in the dimerization domain of Gemin5 modulates protein interactions and translation regulationFrancisco-Velilla, Rosario CSIC ORCID; Embarc-Buh, Azman; Abellan, Salvador; Caño-Ochoa, Francisco del CSIC ORCID; Ramón-Maiques, Santiago CSIC ORCID ; Martínez-Salas, Encarnación CSIC ORCIDartículo
closedAccessaccesoRestringido.pdf.jpg24-feb-2006Structural bases of feed-back control of arginine biosynthesis, revealed by the structures of two hexameric N-acetylglutamate kinases, from Thermotoga maritima and Pseudomonas aeruginosaRamón-Maiques, Santiago CSIC ORCID ; Fernández-Murga, María Leonor CSIC; Gil-Ortiz, Fernando CSIC ORCID; Vagin, Alexei; Fita, Ignacio CSIC ORCID ; Rubio, Vicente CSIC ORCID artículo
openAccessMartínez-SalasE_StructuralBasis.pdf.jpg18-nov-2019Structural basis for the dimerization of Gemin5 and its role in protein recruitment and translation controlMoreno-Morcillo, María CSIC ORCID; Francisco-Velilla, Rosario CSIC ORCID; Embarc-Buh, Azman; Fernández-Chamorro, Javier; Ramón-Maiques, Santiago CSIC ORCID ; Martínez-Salas, Encarnación CSIC ORCIDartículo
openAccessRamón-MaiquesS_StructuralInsight.pdf.jpg6-jun-2017Structural Insight into the Core of CAD, the Multifunctional Protein Leading De Novo Pyrimidine BiosynthesisMoreno-Morcillo, María CSIC ORCID; Grande-García, Araceli; Ruiz-Ramos, Alba; Caño-Ochoa, Francisco del CSIC ORCID; Boskovic, Jasminka; Ramón-Maiques, Santiago CSIC ORCID artículo
closedAccessaccesoRestringido.pdf.jpg2016Structure and Functional Characterization of Human Aspartate Transcarbamoylase, the Target of the Anti-tumoral Drug PALARuiz-Ramos, A.; Velázquez-Campoy, Adrián; Grande-García, Araceli; Moreno-Morcillo, M.; Ramón-Maiques, Santiago CSIC ORCID artículo
closedAccessaccesoRestringido.pdf.jpg2002Structure of acetylglutamate kinase, a key enzyme for arginine biosynthesis and a prototype for the amino acid kinase enzyme family, during catalysisRamón-Maiques, Santiago CSIC ORCID ; Marina, Alberto CSIC ORCID ; Gil-Ortiz, Fernando CSIC ORCID; Fita, Ignacio CSIC ORCID ; Rubio, Vicente CSIC ORCID artículo
closedAccessaccesoRestringido.pdf.jpg2010Substrate binding and catalysis in carbamate kinase ascertained by crystallographic and site-directed mutagenesis studies: movements and significance of a unique globular subdomain of this key enzyme for fermentative ATP production in bacteriaRamón-Maiques, Santiago CSIC ORCID ; Marina, Alberto CSIC ORCID ; Guinot, Anna CSIC; Gil-Ortiz, Fernando CSIC ORCID; Uriarte, Matxalen; Fita, Ignacio CSIC ORCID ; Rubio, Vicente CSIC ORCID artículo
closedAccessaccesoRestringido.pdf.jpg2-jun-2000The 1.5 Å resolution crystal structure of the carbamate kinase-like carbamoyl phosphate synthetase from the hyperthermophilic archaeon Pyrococcus furiosus, bound to ADP, confirms that this thermostable enzyme is a carbamate kinase, and a provides insight into substrate binding and stability in carbamate kinasesRamón-Maiques, Santiago CSIC ORCID ; Marina, Alberto CSIC ORCID ; Uriarte, Matxalen; Fita, Ignacio CSIC ORCID ; Rubio, Vicente CSIC ORCID artículo
closedAccessaccesoRestringido.pdf.jpg1-ago-2003The course of phosphorus in the reaction of N-Acetyl-L-glutamate kinase, determined from the structures of crystalline complexes, including a complex with an AlF4 - transition state mimicGil-Ortiz, Fernando CSIC ORCID; Ramón-Maiques, Santiago CSIC ORCID ; Fita, Ignacio CSIC ORCID ; Rubio, Vicente CSIC ORCID artículo
openAccessRamónMaiquesS_The GATA3 X308_Splice.pdf.jpg25-jun-2020The GATA3 X308_Splice breast cancer mutation is a hormone context-dependent oncogenic driverHruschka, Natascha; Kalisz, Mark; Subijana, María; Graña-Castro, Osvaldo; Caño-Ochoa, Francisco del CSIC ORCID; Paré Brunet, Laia; Sagrera, Ana; Reynies, Aurelien De; Kloesh, Bernhard; Chin, Suet-Feung; Burgués, Octavio; Andreu, David; Bermejo, Begoña; Cejalvo, Juan Miguel; Sutton, Joe; Caldas, Carlos; Ramón-Maiques, Santiago CSIC ORCID ; Carroll, Jason S.; Prat, Aleix; Real, Francisco X.; Martinelli, Paolaartículo
closedAccessaccesoRestringido.pdf.jpg2010Two crystal structures of Escherichia coli N-acetyl-l-glutamate kinase demonstrate the cycling between open and closed conformationsGil-Ortiz, Fernando CSIC ORCID; Ramón-Maiques, Santiago CSIC ORCID ; Fernández-Murga, María Leonor CSIC; Rubio, Vicente CSIC ORCID artículo
openAccess5-oct-2022Use of an interactomics pipeline to assess the potential of new antivirals against SARS-CoV-2Marina Moreno, Alberto; Forcada-Nadal, Alicia CSIC ORCID; Adhav, Anmol CSIC ORCID; Rubio del Campo, Antonio CSIC ORCID; Sanz-Frasquet, Carla CSIC; Marco-Marín, Clara CSIC ORCID; Bravo Sicilia, Jerónimo; Llacer Guerri, Jose Luis; Peréz-Pérez, María-Jesús CSIC ORCID ; López-Redondo, Marisa CSIC; Hernández-Sierra, María Pilar; Gargantilla, Marta CSIC ORCID; Ruiz Partida, Rafa; Gozalbo-Rovira, Roberto CSIC ORCID ; Ramón-Maiques, Santiago CSIC ORCID ; Zamora Caballero, Sara CSIC ORCID; Martín Santamaría, Sonsoles; Rubio, Vicente CSIC ORCID comunicación de congreso
openAccessOrigins_coevolution_diversity_synthesis_life.pdf.jpg2021White Paper 2: Origins, (Co)Evolution, Diversity & Synthesis Of LifeMarco de Lucas, Jesús Eugenio; Moreno-Arribas, M. Victoria CSIC ORCID ; Bovolenta, Paola CSIC ORCID; Manzanares, Miguel CSIC ORCID; Buceta, Javier CSIC ORCID ; Briones, Carlos CSIC ORCID; Jiménez-Serra, Izaskun CSIC ORCID; Valpuesta, José M. CSIC ORCID ; Ramón-Maiques, Santiago CSIC ORCID ; Zardoya, Rafael CSIC ORCID ; Riesgo Gil, Ana ; Casares, Fernando CSIC ORCID; Maeso, Ignacio CSIC ORCID; Valverde, Sergi CSIC ORCID ; Ares, Saúl CSIC ORCID ; Lalueza-Fox, Carles CSIC ORCID ; Torre, Ignacio de la ; Elena, Santiago F. CSIC ORCID ; Comas, Iñaki CSIC ORCID ; Rivas, Germán CSIC ORCID CVN ; García, Evalibro