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closedAccessaccesoRestringido.pdf.jpg1-dic-2022S-Adenosyl-L-methionine treatment provides neuroprotection in a NPC type C mice model through the restoration of membrane fluidity and mitochondrial GSH replenishmentGoicoechea, Leire CSIC ORCID; Fernández-Checa, José C. CSIC ORCID; García-Ruiz, Carmen CSIC ORCID ; Torres, Sandra CSIC ORCID; Nuñez, Susana CSICpóster de congreso
closedAccessaccesoRestringido.pdf.jpg1-jun-2015Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity.Win, Sanda; Than, Tinaung; Le, Bao Han; García-Ruiz, Carmen CSIC ORCID ; Fernández-Checa, José C. CSIC ORCID; Kaplowitz, Neilartículo
closedAccessaccesoRestringido.pdf.jpg1998Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factorColell Riera, Anna CSIC ORCID; García-Ruiz, Carmen CSIC ORCID ; Miranda, Merge; Ardite, Esther; Marí, Montserrat CSIC ORCID ; Morales, Albert CSIC ORCID; Corrales, Fernando J. CSIC ORCID ; Kaplowitz, Neil; Fernández-Checa, José C. CSIC ORCIDartículo
closedAccessaccesoRestringido.pdf.jpg30-dic-2003Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletionColl, Olga; Colell Riera, Anna CSIC ORCID; García-Ruiz, Carmen CSIC ORCID ; Kaplowitz, Neil; Fernández-Checa, José C. CSIC ORCIDartículo
closedAccessaccesoRestringido.pdf.jpg2010Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis. Impact on mitochondrial S-adenosyl-L-methionine and glutathioneCaballero, Francisco CSIC; Fernández, Anna; Matías, Nuria CSIC; Martínez, Laura CSIC; Fucho, Raquel CSIC ORCID; Elena, Montserrat; Caballería, Juan; Morales, Albert CSIC ORCID; Fernández-Checa, José C. CSIC ORCID; García-Ruiz, Carmen CSIC ORCID artículo
closedAccessaccesoRestringido.pdf.jpg7-sep-2022Sphingolipids in health and disease (I)García-Ruiz, Carmen CSIC ORCID comunicación de congreso
openAccess2020Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitisKoh, Eun Hee; Yoon, Ji Eun; Ko, Myoung Seok; Leem, Jaechan; Yun, Ji-Young; Hong, Chung Hwan; Cho, Yun Kyung; Lee, Seung Eun; Jang, Jung Eun; Baek, Ji Yeon; Yoo, Hyun Ju; Kim, Su Jung; Sung, Chang Ohk; Lim, Joon Seo; Jeong, Won-Il; Back, Sung Hoon; Baek, In‐Jeoung; Torres, Sandra CSIC ORCID; Solsona-Vilarrasa, Estel CSIC ORCID; Conde de la Rosa, Laura CSIC ORCID ; García-Ruiz, Carmen CSIC ORCID ; Feldstein, Ariel E.; Fernández-Checa, José C. CSIC ORCID; Lee, Ki‐Upartículo
openAccessbiomolecules-10-01497.pdf.jpg30-oct-2020Sphingomyelinases and Liver DiseasesInsausti, Naroa CSIC ORCID; Solsona-Vilarrasa, Estel CSIC ORCID; García-Ruiz, Carmen CSIC ORCID ; Fernández-Checa, José C. CSIC ORCIDartículo
openAccess2022Sphingosine 1-Phosphate Receptor 4 Promotes Nonalcoholic Steatohepatitis by Activating NLRP3 InflammasomeHong, Chung Hwan; Ko, Myoung Seok; Kim, Su Jung; Cho, Hyunkyung; Lee, Chi-Ho; Yoon, Ji Eun; Yun, Ji-Young; Baek, In‐Jeoung; Jang, Jung Eun; Lee, Seung Eun; Cho, Yun Kyung; Baek, Ji Yeon; Oh, Soo Jin; Lee, Bong Yong; Lim, Joon Seo; Lee, Jongkook; Hartig, Sean M.; Conde de la Rosa, Laura CSIC ORCID ; García-Ruiz, Carmen CSIC ORCID ; Lee, Ki‐Up; Fernández-Checa, José C. CSIC ORCID; Choi, Ji Woong; Kim, Sanghee; Koh, Eun Heeartículo
openAccessHepatology - 2021 - G rate‐Rasc n - Splicing Factor SLU7 Prevents Oxidative Stress‐Mediated Hepatocyte Nuclear Factor 4 .pdf.jpgnov-2021Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte Nuclear Factor 4α Degradation, Preserving Hepatic Differentiation and Protecting From Liver DamageGárate-Rascón, María; Recalde, Miriam; Jimenez, Maddalen; Elizalde, María; Azkona, María; Uriarte, Iker; Latasa, Maria U.; Urtasun, Raquel; Bilbao, Idoia; Sangro, Bruno; García-Ruiz, Carmen CSIC ORCID ; Fernández-Checa, José C. CSIC ORCID; Corrales, Fernando J. CSIC ORCID ; Esquivel, Argitxu; Pineda-Lucena, Antonio CSIC ORCID; Fernández-Barrena, Maite G.; Ávila, Matías A. CSIC ORCID; Arechederra, María; Berasain, Carmenartículo
openAccess5-ene-2020STARD1 and NPC1 expression as pathological markers associated with astrogliosis in post-mortem brains from patients with Alzheimer's disease and Down syndromeArenas, Fabian CSIC ORCID; Castro, Fernanda; Nuñez, Susana CSIC; Gay, Gemma; García-Ruiz, Carmen CSIC ORCID ; Fernández-Checa, José C. CSIC ORCIDartículo
closedAccessaccesoRestringido.pdf.jpg4-nov-2022StARD1 overexpression exacerbates diet-included nash pathology in frgn mice whit humanized liverSegalés, Paula CSIC; Insausti, Naroa CSIC ORCID; Nuñez, Susana CSIC; Fábrega, Laura; Solsona-Vilarrasa, Estel CSIC ORCID; Conde de la Rosa, Laura CSIC ORCID ; Fernández-Checa, José C. CSIC ORCID; García-Ruiz, Carmen CSIC ORCID comunicación de congreso
openAccessCheca - Journal of Hepatology 74 1429-1441 (2021) -  Pre-proof_compressed.pdf.jpgjun-2021STARD1 promotes NASH-driven HCC by sustaining the generation of bile acids through the alternative mitochondrial pathwayConde de la Rosa, Laura CSIC ORCID ; García-Ruiz, Carmen CSIC ORCID ; Vallejo, Carmen CSIC; Baulies, Anna CSIC ORCID; Nuñez, Susana CSIC; Monte, Maria J.; Marín, José J. G.; Baila-Rueda, Lucía; Cenarro, Ana; Civeira, Fernando; Fuster, Josep; García-Valdecasas, Juan Carlos; Ferrer, Joana; Karin, Michael; Ribas, Vicent CSIC ORCID; Fernández-Checa, José C. CSIC ORCIDartículo
closedAccess6-nov-2023Stard1-dependent mitochondrial GSH status determines the hepatotoxicity of bile acids and cholestatic liver diseaseConde de la Rosa, Laura CSIC ORCID; Fábrega, Laura; Nuñez, Susana CSIC; Rivas, Vicent; Segalés, Paula CSIC; Espinosa-Escudero, Ricardo; Solsona-Vilarrasa, Estel CSIC ORCID; Marín, José J. G.; García-Ruiz, Carmen CSIC ORCID póster de congreso
openAccessSTATINS AND PROTEIN PRENYLATION.pdf.jpg2012Statins and protein prenylation in cancer cell biology and therapyGarcía-Ruiz, Carmen CSIC ORCID ; Morales, Albert CSIC ORCID; Fernández-Checa, José C. CSIC ORCIDartículo
closedAccessaccesoRestringido.pdf.jpg4-nov-2022Synergism between loss of von hippel-lindau protein and nutritional cholesterol intake promotes nonalcoholic steatohepatitsConde de la Rosa, Laura CSIC ORCID ; Van Helden, Lauretta; Segalés, Paula CSIC; Nuñez, Susana CSIC; García-Ruiz, Carmen CSIC ORCID ; Fernández-Checa, José C. CSIC ORCIDcomunicación de congreso
openAccessTargeting cholesterol at different.pdf.jpg2011Targeting cholesterol at different levels in the mevalonate pathway protects fatty liver against ischemia-reperfusion injuryLlacuna Duran, Laura CSIC; Fernández, Anna; Montfort, Claudia von CSIC; Matías, Nuria CSIC; Martínez, Laura CSIC; Caballero, Francisco CSIC; Rimola, Antoni; Elena, Montserrat; Morales, Albert CSIC ORCID; Fernández-Checa, José C. CSIC ORCID; García-Ruiz, Carmen CSIC ORCID artículo
closedAccessaccesoRestringido.pdf.jpg22-abr-2015Targeting glucosylceramide synthase increases sorafenib efficacy and evades sorafenib resistance in HCC modelsStefanovic, Milica CSIC; Tutusaus, Anna CSIC ORCID; Bárcena, Cristina CSIC ORCID; Martínez-Nieto, Guillermo A. CSIC; Marí, Montserrat CSIC ORCID ; García-Ruiz, Carmen CSIC ORCID ; Fernández-Checa, José C. CSIC ORCID; Morales, Albert CSIC ORCIDpóster de congreso
openAccessTargeting glucosylceramide-Stefanovic.pdf.jpg22-ene-2016Targeting glucosylceramide synthase upregulation reverts sorafenib resistance in experimental hepatocellular carcinomaStefanovic, Milica CSIC; Tutusaus, Anna CSIC ORCID; Martínez-Nieto, Guillermo A. CSIC; Bárcena, Cristina CSIC ORCID; Gregorio, Estefanía de CSIC; Barbero-Camps, Elisabet CSIC; Colell Riera, Anna CSIC ORCID; Marí, Montserrat CSIC ORCID ; García-Ruiz, Carmen CSIC ORCID ; Fernández-Checa, José C. CSIC ORCID; Morales, Albert CSIC ORCIDartículo
openAccessLiver International - 2023 - Córdoba‐Jover - Tcf20 deficiency is associated with increased liver fibrogenesis and.pdf.jpgago-2023Tcf20 deficiency is associated with increased liver fibrogenesis and alterations in mitochondrial metabolism in mice and humansCórdoba-Jover, Bernat; Ribera, Jordi; Portolés, Irene; Lecue, Elena; Rodriguez-Vita, Juan; Pérez-Sisqués, Leticia; Mannara, Francesco; Solsona-Vilarrasa, Estel CSIC ORCID; Garcia-Ruiz, Carmen ; Fernández-Checa, José C. CSIC ORCID; Casals, Gregori; Rodríguez-Revenga, Laia; Álvarez-Mora, María Isabel; Arteche-López, Ana; Díaz de Bustamante, Aranzazu; Calvo, Rosa; Pujol, Anna; Azkargorta, Mikel; Elortza, Felix; Malagelada, Cristina; Pinyol, Roser; Huguet-Pradell, Júlia; Melgar-Lesmes, Pedro; Jiménez, Wladimiro; Morales-Ruiz, Manuelartículo