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| Título: | StARD1 overexpression exacerbates diet-included nash pathology in frgn mice whit humanized liver |
Autor: | Segalés, Paula CSIC; Insausti, Naroa CSIC ORCID; Nuñez, Susana CSIC; Fábrega, Laura; Solsona-Vilarrasa, Estel CSIC ORCID; Conde de la Rosa, Laura CSIC ORCID ; Fernández-Checa, José C. CSIC ORCID; García-Ruiz, Carmen CSIC ORCID | Fecha de publicación: | 4-nov-2022 | Citación: | The Liver Meeting (2022) | Resumen: | Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease due to its association with obesity and type II diabetes. The presence of fibrosis indicates disease progression towards cirrhosis and hepatocellular carcinoma (HCC). Trafficking of cholesterol to mitochondria through increased expression of steroidogenic acute regulatory protein 1 (STARD1) has been described as a key factor for NAFLD progression. If this increase of STARD1 is cause or consequence, is still unknown. To examine this question we used a nutritional model of NASH with translational relevance to human disease with the aim to investigate the contribution of STARD1 in the progression of NASH in FRGN mice with humanized liver | Descripción: | Trabajo presentado en el The Liver Meeting, celebrado en Washington, D.C. (Estados Unidos), del 4 al 8 de noviembre de 2022 | URI: | http://hdl.handle.net/10261/305727 |
| Aparece en las colecciones: | (IIBB) Comunicaciones congresos |
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