Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/98788
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Guzmán, Rodrigo | - |
dc.contributor.author | Nardecchia, Stefania | - |
dc.contributor.author | Gutiérrez, María C. | - |
dc.contributor.author | Ferrer, M. Luisa | - |
dc.contributor.author | Ramos, Viviana | - |
dc.contributor.author | Monte, Francisco del | - |
dc.contributor.author | Abarrategi, Ander | - |
dc.contributor.author | López-Lacomba, José Luis | - |
dc.date.accessioned | 2014-06-23T13:16:35Z | - |
dc.date.available | 2014-06-23T13:16:35Z | - |
dc.date.issued | 2014 | - |
dc.identifier | doi: 10.1371/journal.pone.0087149 | - |
dc.identifier | issn: 1932-6203 | - |
dc.identifier.citation | PLoS ONE 9(2): e87419 (2014) | - |
dc.identifier.uri | http://hdl.handle.net/10261/98788 | - |
dc.description | This is an open-access article distributed under the terms of the Creative Commons Attribution License. | - |
dc.description.abstract | Numerous strategies that are currently used to regenerate bone depend on employing biocompatible materials exhibiting a scaffold structure. These scaffolds can be manufactured containing particular active compounds, such as hydroxyapatite precursors and/or different growth factors to enhance bone regeneration process. Herein, we have immobilized calcium phosphate salts (CPS) and bone morphogenetic protein 2 (BMP-2) - combined or alone - into chitosan scaffolds using ISISA process. We have analyzed whether the immobilized bone morphogenetic protein preserved its osteoinductive capability after manufacturing process as well as BMP-2 in vitro release kinetic. We have also studied both the in vitro and in vivo biocompatibility of the resulting scaffolds using a rabbit model. Results indicated that rhBMP-2 remained active in the scaffolds after the manufacturing process and that its release kinetic was different depending on the presence of CPS. In vitro and in vivo findings showed that cells grew more in scaffolds with both CPS and rhBMP-2 and that these scaffolds induced more bone formation in rabbit tibia. Thus chitosan scaffolds containing both CPS and rhBMP-2 were more osteoinductive than their counterparts alone indicating that could be useful for bone regeneration purposes, such as some applications in dentistry. Copyright: © 2014 Guzmán et al. | - |
dc.description.sponsorship | This work was supported by Spanish Ministry of Economy and Competitiveness (MINECO) (CONSOLIDER project CSD2009-00088), Ministerio de Ciencia e Innovación (MAT2009-10214, MAT2011-25329, MAT2012-34811, SAF2011-27863) and Seventh Framework Programme of the European Commission (EuroNanomed ERA-NET initiative, REBONE project; PI10/02985FIS). | - |
dc.publisher | Public Library of Science | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.title | Chitosan scaffolds containing calcium phosphate salts and rhBMP-2: In vitro and in vivo testing for bone tissue regeneration | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1371/journal.pone.0087149 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1371/journal.pone.0087149 | - |
dc.date.updated | 2014-06-23T13:16:35Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.rights.license | http://creativecommons.org/licenses/by/4.0/ | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.identifier.pmid | 24504411 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
Aparece en las colecciones: | (ICMM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Chitosan Scaffolds.pdf | 1,94 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
9
checked on 11-may-2024
SCOPUSTM
Citations
30
checked on 11-may-2024
WEB OF SCIENCETM
Citations
27
checked on 23-feb-2024
Page view(s)
296
checked on 11-may-2024
Download(s)
294
checked on 11-may-2024