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Title

Asymmetric formal carbonyl-ene reactions of formaldehyde tert -butyl hydrazone with α-keto esters: Dual activation by bis-urea catalysts

AuthorsCrespo-Peña, Ana; Monge, David; Martín-Zamora, Eloísa; Álvarez, Eleuterio ; Fernández, Rafael ; Lassaletta, José M.
Issue Date2012
PublisherAmerican Chemical Society
CitationJournal of the American Chemical Society 134: 12912- 12915 (2012)
AbstractThe dual activation of α-keto esters and formaldehyde tert-butyl hydrazone by BINAM-derived bis-ureas is the key to achieve high reactivity and excellent enantioselectivities in nucleophilic addition (formal carbonyl-ene reaction) to functionalized tertiary carbinols. Ensuing high-yielding diazene-to-aldehyde tranformations and subsequent derivatizations provides a direct entry to a variety of densely functionalized products. © 2012 American Chemical Society.
URIhttp://hdl.handle.net/10261/96601
DOI10.1021/ja305209w
Identifiersdoi: 10.1021/ja305209w
issn: 0002-7863
Appears in Collections:(IIQ) Artículos
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