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| Título: | The extradomain A of fibronectin (EDA) combined with poly(I: C) enhances the immune response to HIV-1 p24 protein and the protection against recombinant Listeria monocytogenes-Gag infection in the mouse model |
Autor: | San Román, Beatriz CSIC ORCID ; Andrés, Ximena de CSIC; Muñoz, Pilar M. CSIC ORCID; Obregón, Patricia CSIC; Asensio, Aaron C.; Garrido, Victoria CSIC ORCID ; Andrés, Damián F. de CSIC ORCID ; Amorena Zabalza, Beatriz CSIC ORCID ; Grilló, María Jesús CSIC ORCID | Fecha de publicación: | 28-mar-2012 | Editor: | Elsevier | Citación: | Vaccine 30(15): 2564-2569 (2012) | Resumen: | The development of effective vaccines against HIV-1 infection constitutes one of the major challenges in viral immunology. One of the protein candidates in vaccination against this virus is p24, since it is a conserved HIV antigen that has cytotoxic and helper T cell epitopes as well as B cell epitopes that may jointly confer enhanced protection against infection when used in immunization-challenge approaches. In this context, the adjuvant effect of EDA (used as EDAp24 fusion protein) and poly(I:C), as agonists of TLR4 and TLR3, respectively, was assessed in p24 immunizations using a recombinant Listeria monocytogenes HIV-1 Gag proteins (Lm-Gag, where p24 is the major antigen) for challenge in mice. Immunization with EDAp24 fusion protein together with poly(I:C) adjuvant induced a specific p24 IFN-γ production (Th1 profile) as well as protection against a Lm-Gag challenge, suggesting an additive or synergistic effect between both adjuvants. The combination of EDA (as a fusion protein with the antigen, which may favor antigen targeting to dendritic cells through TLR4) and poly(I:C) could thus be a good adjuvant candidate to enhance the immune response against HIV-1 proteins and its use may open new ways in vaccine investigations on this virus. © 2012 Elsevier Ltd. | Descripción: | San Román, Beatriz et al. | Versión del editor: | http://dx.doi.org/10.1016/j.vaccine.2012.01.081 | URI: | http://hdl.handle.net/10261/86863 | DOI: | 10.1016/j.vaccine.2012.01.081 | Identificadores: | doi: 10.1016/j.vaccine.2012.01.081 issn: 0264-410X |
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| extradomain_a_fibronectin_San_Roman.pdf | 284,95 kB | Adobe PDF |  Visualizar/Abrir |
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