Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/66558
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Genome-wide distribution of DNA replication origins at A+T-rich islands in Schizosaccharomyces pombe |
Autor: | Segurado, Mónica CSIC ORCID; Luis, Alberto de CSIC; Antequera, Francisco CSIC ORCID | Fecha de publicación: | 2003 | Editor: | Nature Publishing Group | Citación: | EMBO Reports 14(4): 1048-1053 (2003) | Resumen: | Genome-wide analysis of replication dynamics requires the previous identification of DNA replication origins (ORIs). However, variability among the ORIs makes it difficult to predict their distribution across the genome on the basis of their sequence. We report here that ORIs in Schizosaccharomyces pombe coincide with discrete chromosomal A+T-rich islands of up to 1 kb long that are characterized by a distinctive A+T content that clearly differentiates them from the rest of the genome. Genome-wide analysis has enabled us to identify 384 of these regions, which predicts the position of most ORIs in the genome, as shown by functional replication analyses. A+T-rich islands occur at the mating locus, centromeres and subtelomeric regions at a density that is approximately fourfold higher than elsewhere in the genome, which suggests a link between the origin recognition complex (ORC) and transcriptional silencing in these regions. The absence of consensus elements in A+T-rich islands implies that different sequences can target the ORC to different ORIs. | Versión del editor: | http://dx.doi.org/10.1038/sj.embor.7400008 | URI: | http://hdl.handle.net/10261/66558 | DOI: | 10.1038/sj.embor.7400008 | Identificadores: | doi: 10.1038/sj.embor.7400008 issn: 1469-221X e-issn: 1469-3178 |
Aparece en las colecciones: | (IMB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Genome-wide distribution of DNA.pdf | 233,78 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
77
checked on 20-abr-2024
SCOPUSTM
Citations
134
checked on 07-may-2024
WEB OF SCIENCETM
Citations
125
checked on 28-feb-2024
Page view(s)
355
checked on 07-may-2024
Download(s)
238
checked on 07-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.