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dc.contributor.author | Ariza-Cosano, Ana | - |
dc.contributor.author | Visel, Axel | - |
dc.contributor.author | Pennacchio, Len A. | - |
dc.contributor.author | Fraser, Hunter B. | - |
dc.contributor.author | Gómez-Skarmeta, José Luis | - |
dc.contributor.author | Irimia, Manuel | - |
dc.contributor.author | Bessa, José | - |
dc.date.accessioned | 2013-01-15T06:16:36Z | - |
dc.date.available | 2013-01-15T06:16:36Z | - |
dc.date.issued | 2012-12-19 | - |
dc.identifier.citation | BMC Genomics 13(1): 713 (2012) | - |
dc.identifier.issn | 1471-2164 | - |
dc.identifier.uri | http://hdl.handle.net/10261/64085 | - |
dc.description | This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. | - |
dc.description.abstract | [Background]: Phenotypic evolution in animals is thought to be driven in large part by differences in gene expression patterns, which can result from sequence changes in cis-regulatory elements (cis-changes) or from changes in the expression pattern or function of transcription factors (trans-changes). While isolated examples of trans-changes have been identified, the scale of their overall contribution to regulatory and phenotypic evolution remains unclear. [Results]: Here, we attempt to examine the prevalence of trans-effects and their potential impact on gene expression patterns in vertebrate evolution by comparing the function of identical human tissue-specific enhancer sequences in two highly divergent vertebrate model systems, mouse and zebrafish. Among 47 human conserved non-coding elements (CNEs) tested in transgenic mouse embryos and in stable zebrafish lines, at least one species-specific expression domain was observed in the majority (83%) of cases, and 36% presented dramatically different expression patterns between the two species. Although some of these discrepancies may be due to the use of different transgenesis systems in mouse and zebrafish, in some instances we found an association between differences in enhancer activity and changes in the endogenous gene expression patterns between mouse and zebrafish, suggesting a potential role for trans-changes in the evolution of gene expression. [Conclusions]: In total, our results: (i) serve as a cautionary tale for studies investigating the role of human enhancers in different model organisms, and (ii) suggest that changes in the trans environment may play a significant role in the evolution of gene expression in vertebrates. | - |
dc.description.sponsorship | This study was supported by the Spanish and Andalusian Governments (JLGS grant numbers BFU2010-14839, CSD2007-00008 and Proyecto de Excelencia CVI-3488) and National Institute of Health (HBF grant number 1R21HG005240-01A1). AA is a FPI fellow and J.B. is a Juan de la Cierva postdoctoral fellow of the Consejo Superior de Investigaciones Cientificas. | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.title | Differences in enhancer activity in mouse and zebrafish reporter assays are often associated with changes in gene expression | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1186/1471-2164-13-713 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1186/1471-2164-13-713 | - |
dc.date.updated | 2013-01-15T06:16:37Z | - |
dc.description.version | Peer Reviewed | - |
dc.rights.license | http://creativecommons.org/licenses/by/2.0 | - |
dc.contributor.funder | Junta de Andalucía | - |
dc.contributor.funder | National Institutes of Health (US) | - |
dc.contributor.funder | Consejo Superior de Investigaciones Científicas (España) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/100000002 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003339 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011011 | es_ES |
dc.identifier.pmid | 23253453 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.openairetype | artículo | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
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