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| Título: | Platinum complexes for multi-parametric assays using microarray systems |
Autor: | González, María; Bartolomé, Raquel; Matarraz, Sergio; Pérez-Andrés, Martin CSIC ORCID CVN; Orfao, Alberto CSIC ORCID ; Fuentes, Manuel CSIC ORCID ; Criado, Julio J. | Fecha de publicación: | 2012 | Editor: | Elsevier | Citación: | Journal of Inorganic Biochemistry 106(1): 43-45 (2012) | Resumen: | Here, we present a two novel fluorescent dyes ethylenediaminechlorocholylglycinateplatinum(II), [Pt(CG)Cl(en)] complex 1 and bisursodeoxycholate(ethylenediamine)platinum(II), [Pt(UDC)2(en)] complex 2 based on well-known cis-platin chemistry. These platinum complexes contain cholylglycinate (CG) and ursodeoxycholate (UDC) as ligands. These compounds enable qualitative detection of double-helix DNA and quantitative detection (from pg to μg). These novel compounds have absorption and emission spectra in a difference range as the common ones (for example: cyanine dyes such as Cy3, Cy5, Cy7,...); therefore, it could allow the multi-parametric detection of DNA arrays, incrementing the capacity of experimental performance per one single array. As a consequence, it will increase the amount of data info obtained per chip. The combination of the intrinsic property of this compounds with the optical properties in different fluorescence channels, can allow introducing a new molecule with a wide range of possible applications in DNA arrays. © 2011 Elsevier Inc. All rights reserved. | Descripción: | et al. | URI: | http://hdl.handle.net/10261/62617 | DOI: | 10.1016/j.jinorgbio.2011.08.015 | Identificadores: | doi: 10.1016/j.jinorgbio.2011.08.015 issn: 0162-0134 |
| Aparece en las colecciones: | (IBMCC) Artículos |
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