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Platinum complexes for multi-parametric assays using microarray systems

AuthorsGonzález, María; Bartolomé, Raquel; Matarraz, Sergio; Pérez-Andrés, Martin; Orfao, Alberto ; Fuentes, Manuel ; Criado, Julio J.
Issue Date2012
CitationJournal of Inorganic Biochemistry 106(1): 43-45 (2012)
AbstractHere, we present a two novel fluorescent dyes ethylenediaminechlorocholylglycinateplatinum(II), [Pt(CG)Cl(en)] complex 1 and bisursodeoxycholate(ethylenediamine)platinum(II), [Pt(UDC)2(en)] complex 2 based on well-known cis-platin chemistry. These platinum complexes contain cholylglycinate (CG) and ursodeoxycholate (UDC) as ligands. These compounds enable qualitative detection of double-helix DNA and quantitative detection (from pg to μg). These novel compounds have absorption and emission spectra in a difference range as the common ones (for example: cyanine dyes such as Cy3, Cy5, Cy7,...); therefore, it could allow the multi-parametric detection of DNA arrays, incrementing the capacity of experimental performance per one single array. As a consequence, it will increase the amount of data info obtained per chip. The combination of the intrinsic property of this compounds with the optical properties in different fluorescence channels, can allow introducing a new molecule with a wide range of possible applications in DNA arrays. © 2011 Elsevier Inc. All rights reserved.
Descriptionet al.
Identifiersdoi: 10.1016/j.jinorgbio.2011.08.015
issn: 0162-0134
Appears in Collections:(IBMCC) Artículos
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