Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/60612
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | García-López, Jesús | - |
dc.contributor.author | Del Mazo, Jesús | - |
dc.date.accessioned | 2012-11-20T09:44:25Z | - |
dc.date.available | 2012-11-20T09:44:25Z | - |
dc.date.issued | 2012-08 | - |
dc.identifier.citation | BBA - Biochimica et Biophysica Acta, 1819 (8) : 847–854 (2012) | es_ES |
dc.identifier.issn | 0006-3002 | - |
dc.identifier.uri | http://hdl.handle.net/10261/60612 | - |
dc.description | 8 páginas, 4 figuras, 2 tablas suplementarias -- PAGS nros. 847-854 | es_ES |
dc.description.abstract | The role of microRNAs (miRNAs) in early development, and particularly in the post-transcriptional regulation of maternal mRNAs remains controversial. Hence, we have assessed how miRNA processing is regulated during preimplantation mouse development, from the fully-grown oocyte to the blastocyst, quantifying the expression of genes whose proteins are involved in miRNAs biogenesis and function. The expression of the Drosha, Dgcr8, Exportin 5, Dicer, Ago1, Ago2, Ago3, Ago4 and Ago5 genes was downregulated from the zygotic cleavage stage, except for the increase of Ago1, Ago3 and Ago4 expression in the 2-cell embryo, and of Ago2 in 4- and 8-cell embryos. These findings suggest that the capacity to process miRNAs, by the considered canonical pathway, diminishes after fertilization, primarily reducing miRNA activity in the later stages of preimplantation development. However, by analyzing the different precursor and mature forms of specific miRNAs that are abundantly expressed in the blastocyst, such as miR-292-3p and miR-292-5p, we identified miRNA-duplexes and/or miRNAs bound to target mRNAs that may serve as potential stockpiles of miRNAs. In response to the demand, such stockpile could directly provide functional and mature miRNAs | es_ES |
dc.description.sponsorship | This work was supported by grants from: The European Chemical Industry Council-Long-range Research Initiative (CEFIC-LRi); Ministerio de Ciencia e Innovación, Spain (MICINN) (BFU2004-03977/BFI and FIS PI071007); MEDDTL (11-MRES-PNRPE-9-CVS-072) France, and Consejo Superior de Investigaciones Científicas (PIE 201020E016), Spain | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | MicroRNA | es_ES |
dc.subject | miRNA | es_ES |
dc.subject | preimplantation embryo | es_ES |
dc.subject | Biogenesis | es_ES |
dc.subject | oocyte | es_ES |
dc.subject | Zygote | es_ES |
dc.title | Expression dynamics of microRNA biogenesis during preimplantation mouse development | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/j.bbagrm.2012.03.007 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.bbagrm.2012.03.007 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
Aparece en las colecciones: | (CIB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
García-López et al (2014)BBA-GeneRegulatMech.pdf | 4,44 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
46
checked on 20-may-2024
WEB OF SCIENCETM
Citations
39
checked on 26-feb-2024
Page view(s)
431
checked on 26-may-2024
Download(s)
618
checked on 26-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.