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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | López-Donaire, M. L. | - |
dc.contributor.author | Parra-Cáceres, J. | - |
dc.contributor.author | Fernández-Gutiérrez, Mar | - |
dc.contributor.author | Vázquez Lasa, Blanca | - |
dc.contributor.author | San Román, Julio | - |
dc.date.accessioned | 2012-09-19T08:52:25Z | - |
dc.date.available | 2012-09-19T08:52:25Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Biomacromolecules 11 : 2478–2486 (2010) | es_ES |
dc.identifier.issn | 1525-7797 | - |
dc.identifier.uri | http://hdl.handle.net/10261/56453 | - |
dc.description.abstract | Polymeric drugs based on random copolymers with antimitotic activity were obtained by free radical copolymerization of oleyl 2-acetamido-2-deoxy-R-D-glucopyranoside methacrylate (OAGMA) and 2-ethyl-(2- pyrrolidone) methacrylate (EPM) at low and high conversion and analyzed in terms of microstructure, physicochemical, and biological properties. Reactivity ratios of monomers were found to be rOAGMA ) 1.34 and rEPM ) 0.98, indicating the obtaining of statistical copolymers with random sequence distribution of the comonomeric units in the macromolecular chains. The glass transition temperature of the copolymers presents a negative deviation from the predicted values according to the Fox equation, suggesting a higher flexibility of the alternating diad. Copolymeric systems with OAGMA contents between 10-50 mol % presented thermosensitive behavior in a heating process showing cloud point temperatures (CPT) in the range 45-28 °C with increasing OAGMA content and hysteresis in one heating-and-cooling cycle. In vitro glycolipid release studies revealed the stability of the ester group in culture medium. The polymeric drugs with 30 and 50 mol % OAGMA presented antimitotic activity on a human glioblastoma line, but they were less toxic on normal human fibroblast cultures. | es_ES |
dc.description.sponsorship | Financial support from the Comisio´n Interministerial de Ciencia y Tecnología, CICYT, (MAT2007- 63355) and NoE EXPERTISSUES (UE Contract No. 500283- 2) is gratefully acknowledged | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Chemical Society | es_ES |
dc.rights | closedAccess | es_ES |
dc.title | Polymeric drugs based on random copolymers with antimitotic activity | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1021/bm100672c | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1021/bm100672c | es_ES |
dc.identifier.e-issn | 1526-4602 | - |
dc.contributor.funder | Comisión Interministerial de Ciencia y Tecnología, CICYT (España) | - |
dc.contributor.funder | European Commission | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100007273 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
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