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http://hdl.handle.net/10261/54022
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Siebert, Hans-Christian | - |
dc.contributor.author | Lu, Shan-Yun | - |
dc.contributor.author | Wechselberger, Rainer | - |
dc.contributor.author | Born, Karin | - |
dc.contributor.author | Eckert, Thomas | - |
dc.contributor.author | Liang, Songping | - |
dc.contributor.author | von der Lieth, Claus-Wilhelm | - |
dc.contributor.author | Jiménez-Barbero, Jesús | - |
dc.contributor.author | Schauer, Roland | - |
dc.contributor.author | Vliegenthart, Johannes F.G. | - |
dc.contributor.author | Lütteke, Thomas | - |
dc.contributor.author | Kožár, Tibor | - |
dc.date.accessioned | 2012-07-27T08:14:21Z | - |
dc.date.available | 2012-07-27T08:14:21Z | - |
dc.date.issued | 2009-08 | - |
dc.identifier.citation | Carbohydrate Research 344(12):1515-25(2009) | es_ES |
dc.identifier.issn | 0008-6215 | - |
dc.identifier.uri | http://hdl.handle.net/10261/54022 | - |
dc.description | 12 páginas, 7 figuras, 1 tabla, 2 figuras suplementarias -- PAGS nros. 1515-1525 | es_ES |
dc.description.abstract | The affinity to sialic acid-containing oligosaccharides of the small-animal lectin SHL-I isolated from the venom of the Chinese bird-hunting spider Selenocosmia huwena is here described for the first time. By a strategic combination of NMR techniques, molecular modeling, and data mining tools it was possible to identify the crucial amino acid residues that are responsible for SHL-I’s ability to bind sialic acid residues in a specific way. Furthermore, we are able to discuss the role of the functional groups of sialic acid when bound to SHL-I. Also the impact of Pro31 in its cis- or trans-form on SHL-I’s ligand affinity is of special interest, since it answers the question if Trp32 is a crucial amino acid for stabilizing complexes between SHL-I and sialic acid. SHL-I can be considered as a proper model system that provides further insights into the binding mechanisms of small-animal lectins to sialic acid on a sub-molecular level | es_ES |
dc.description.sponsorship | The authors acknowledge Professor A. J. Olson for providing the autodock program. T. K. acknowledges the Slovak VEGA granting agency for providing support for related Project 2/7053/27 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | Sialic acid | es_ES |
dc.subject | Lectin | es_ES |
dc.subject | Carbohydrate–protein interactions | es_ES |
dc.subject | Molecular modeling | es_ES |
dc.subject | NMR analysis | es_ES |
dc.title | A lectin from the Chinese bird-hunting spider binds sialic acids | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/j.carres.2009.06.002 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.carres.2009.06.002 | es_ES |
dc.identifier.e-issn | 1873-426X | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | artículo | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
Aparece en las colecciones: | (CIB) Artículos |
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