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Low-density lipoprotein density determination by electric conductivity

AuthorsFernández-Higuero, J. A.; Salvador, A. M.; Arrondo, José Luis R.; Milicua, José Carlos G.
Issue Date2011
CitationAnalytical Biochemistry 417(2): 283-285 (2011)
AbstractThe predominance of small dense low-density lipoprotein (LDL) particles is associated with an increased risk of coronary heart disease. A simple but precise method has been developed, based on electrical conductivity of an isopycnic gradient of KBr, to obtain density values of human LDL fraction. The results obtained can distinguish LDL density populations and their subfractions from different patients. These data were corroborated by Fourier transform infrared spectroscopy (FTIR) (structure) and light-scattering analyses (size). © 2011 Elsevier.
Identifiersdoi: 10.1016/j.ab.2011.06.004
issn: 0003-2697
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