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| Título: | Spermine attenuates carotid body glomus cell oxygen sensing by inhibiting L-type Ca2+ channels |
Autor: | Cayzac, S. H.; Rocher, Asunción CSIC ORCID; Obeso, Ana CSIC ORCID; González, Constancio CSIC | Palabras clave: | Carotid body Hypoxia L-type calcium channels Polyamines |
Fecha de publicación: | ene-2011 | Editor: | Elsevier | Citación: | Respiratory Physiology and Neurobiology 175(1): 80-89 (2011) | Resumen: | An increase in intracellular Ca2+ is crucial to O2 sensing by the carotid body. Polyamines have been reported to modulate both the extracellular Ca2+-sensing receptor (CaR) and voltage-gated Ca2+ channels in a number of cell types. Using RT-PCR and immunohistochemistry, the predominant voltage-gated Ca2+ channels expressed in the adult rat carotid body were L (CaV1.2) and N (CaV2.2)-type. CaR mRNA could not be amplified from carotid bodies, but the protein was expressed in the nerve endings. Spermine inhibited the hypoxia-evoked catecholamine release from isolated carotid bodies and attenuated the depolarization- and hypoxia-evoked Ca2+ influx into isolated glomus cells. In agreement with data from carotid body, recombinant CaV1.2 was also inhibited by spermine. In contrast, the positive allosteric modulator of CaR, R-568, was without effect on hypoxia-induced catecholamine release from carotid bodies and depolarization-evoked Ca2+ influx into glomus cells. These data show that spermine exerts a negative influence on carotid body O2 sensing by inhibiting L-type Ca2+ channels. | Descripción: | 10 páginas, 7 figuras, 1 tabla.-- et al. | Versión del editor: | http://dx.doi.org/10.1016/j.resp.2010.09.009 | URI: | http://hdl.handle.net/10261/49377 | DOI: | 10.1016/j.resp.2010.09.009 | ISSN: | 1569-9048 |
| Aparece en las colecciones: | (IBGM) Artículos |
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