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Título: | Germ cell selection in genetic mosaics in Drosophila melanogaster |
Autor: | Extavour, C.; García-Bellido, Antonio CSIC | Palabras clave: | Drosophila Development Mutations Genes |
Fecha de publicación: | 2001 | Editor: | National Academy of Sciences (U.S.) | Citación: | Proceedings of the National Academy of Sciences 98(20): 11341–11346 (2001) | Resumen: | Heritable mutations in the germ line lead to genetically heterogeneous, or mosaic, gonads. Many of the genes used in germ-line development also play roles in somatic development [Saffman, E. E. & Lasko, P. (1999) Cell. Mol. Life Sci. 55, 1141–1163]. Mutations in these genes may have cellular phenotypes throughout germ-line development leading to their differential elimination or survival, as has been observed in somatic cells [Morata, G. & Ripoll, P. (1975) Dev. Biol. 42, 211–221]. We investigate whether mutations in heterozygosis are subject to pregametic selection in the germ line. We initiated clones of wild-type homozygous cells at different stages of development in gonads heterozygous for eight different recessive chromosome deficiencies. Here we show that cell selection takes place in mosaic germ-line populations. This phenomenon represents a level of selection that precedes and conditions subsequent zygotic selection by affecting the genes available in the gametic population. | Versión del editor: | http://dx.doi.org/10.1073/pnas.201409198 | URI: | http://hdl.handle.net/10261/48353 | DOI: | 10.1073/pnas.201409198 | ISSN: | 1091-6490 |
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