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Title

Autoantibody to NA14 is an independent marker primarily for Sjögren's syndrome

AuthorsNozawa, Kazuhisa; Ríos, Rosa M. ; Chan, Edward K. L.
KeywordsNA14
Sjögren’s syndrome
Autoantigen
Autoantibody
Coiled-Coil Protein
Issue Date2009
PublisherFrontiers in Bioscience Publications
CitationFrontiers in Bioscience 14: 3733-3739 (2009)
AbstractNuclear Autoantigen of 14 kDa (NA14) was originally identified using the serum of a Sjögren's syndrome (SS) patient as probe in screening a human testis cDNA expression library. To date there is no report in the systematic analysis of the prevalence of autoantibodies to NA14. In this study, anti-NA14 was determined in several rheumatic diseases from independent cohorts in the US and Japan. The prevalence of anti-NA14 were 18/132 (13.6%) in primary SS, 0/50 (0%) secondary SS, 2/100 (2%) SLE, 1/43 (2.3%) scleroderma, 0/54 (0%) rheumatoid arthritis, 1/29 (3.4%) polymyositis/dermatomyositis, and 0/58 (0%) normal healthy controls. The frequencies of anti-NA14 positive sera in primary SS are statistically greater than normal healthy controls (p=0.006), secondary SS (p=0.044), and other rheumatic diseases. Furthermore, among 11 anti-NA14 positive primary SS sera, 4/11 (36.3%) sera were negative for both anti-SS-A/Ro and SS-B/La antibodies. Thus anti-NA14 autoantibodies may be useful for the discrimination of primary versus secondary SS and serve as a diagnostic marker for primary SS especially in seronegative (anti-SS-A/Ro and anti-SS-B/La antibodies negative) patients with SS.
Description12 páginas, 2 figuras, 2 tablas.-- El Pdf es el manuscrito de autor.-- et al.
Publisher version (URL)http://dx.doi.org/10.2741/3484
URIhttp://hdl.handle.net/10261/40749
DOI10.2741/3484
ISSN1093-9946
E-ISSN1093-4715
Appears in Collections:(CABIMER) Artículos
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