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Título: | Vertebral osteomyelitis after spine instrumentation surgery: risk factors and management |
Autor: | Benavent, Eva; Kortajarena, Xabier; Sobrino-Díaz, Beatriz; Gasch, Oriol; Rodríguez-Pardo, Dolors; Escudero-Sánchez, Rosa; Bahamonde, Alberto; Rodriguez-Montserrat, David; García-País, María José; Toro, María Dolores del CSIC ORCID; Sorlí, Luisa; Nodar, Andrés; Vilchez, Helem H.; Muñez, Elena; Iribarren, José A.; Ariza, Javier; Murillo, Óscar; Group for the Study of Osteoarticular Infections – Spanish Society of Infectious Diseases and Clinical Microbiology (GEIO-SEIMC) | Palabras clave: | Post-surgical vertebral osteomyelitis Infection after spine instrumentation Device-related infections Orthopaedic surgery Bone and joint infections |
Fecha de publicación: | oct-2023 | Editor: | Elsevier | Citación: | Journal of Hospital Infection 140: 102-109 (2023) | Resumen: | [Background] Vertebral osteomyelitis after spine instrumentation surgery (pVOM) is a rare complication. Most cases of infection occur early after surgery that involve skin and soft tissue and can be managed with debridement, antibiotics, and implant retention (DAIR). [Aim] To identify pVOM risk factors and evaluate management strategies. [Methods] From a multicentre cohort of deep infection after spine instrumentation (IASI) cases (2010–2016), pVOM cases were compared with those without vertebral involvement. Early and late infections were defined (<60 days and >60 days after surgery, respectively). Multivariate analysis was used to explore risk factors. [Findings] Among 410 IASI cases, 19 (4.6%) presented with pVOM, ranging from 2% (7/347) in early to 19.1% (12/63) in late IASIs. After multivariate analysis, age (adjusted odds ratio (aOR): 1.10; 95% confidence interval (CI): 1.03–1.18), interbody fusion (aOR: 6.96; 95% CI: 2–24.18) and coagulase-negative staphylococci (CoNS) infection (aOR: 3.83; 95% CI: 1.01–14.53) remained independent risk factors for pVOM. Cases with pVOM had worse prognoses than those without (failure rate; 26.3% vs 10.8%; P = 0.038). Material removal was the preferred strategy (57.9%), mainly in early cases, without better outcomes (failure rate; 33.3% vs 50% compared with DAIR). Late cases managed with removal had greater success compared with DAIR (failure rate; 0% vs 40%; P = 0.067). [Conclusion] Risk factors for pVOM are old age, use of interbody fusion devices and CoNS aetiology. Although the diagnosis leads to a worse prognosis, material withdrawn should be reserved for late cases or when spinal fusion is achieved. |
Versión del editor: | https://doi.org/10.1016/j.jhin.2023.07.008 | URI: | http://hdl.handle.net/10261/353465 | DOI: | 10.1016/j.jhin.2023.07.008 | ISSN: | 0195-6701 | E-ISSN: | 1532-2939 |
Aparece en las colecciones: | (IBIS) Artículos |
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