Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/351443COMPARTIR / EXPORTAR:
 SHARE
 CORE
BASE
|
|
| Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
| Título: | Brain hypometabolism in non-demented microtubule-associated protein tau H1 carriers with Parkinson's disease |
Autor: | Gasca-Salas, Carmen; Trompeta, Clara; López-Aguirre, Miguel; Rodríguez Rojas, Rafael; Clarimon, Jordi; Dols-Icardo, Oriol; El Bounasri, Shaimaa; Guida, Pasqualina; Mata-Marín, David; Hernández-Fernández, Frida; Marras, Connie; García-Cañamaque, Lina; Plaza de Las Heras, Isabel; Obeso, Ignacio CSIC ORCID ; Vela, Lydia; Fernández-Rodríguez, Beatriz | Palabras clave: | Hypometabolism MAPT gene Parkinson's disease Cognitive impairment |
Fecha de publicación: | nov-2023 | Editor: | John Wiley & Sons | Citación: | Journal of Neuroimaging | Resumen: | The microtubule-associated protein tau (MAPT) H1 homozygosity (H1/H1 haplotype) is a genetic risk factor for neurodegenerative diseases, such as Parkinson's disease (PD). MAPT H1 homozygosity has been associated with conversion to PD; however, results are conflicting since some studies did not find a strong influence. Cortical hypometabolism is associated with cognitive impairment in PD. In this study, we aimed to evaluate the metabolic pattern in nondemented PD patients MAPT H1/H1 carriers in comparison with MAPT H1/H2 haplotype. In addition, we evaluated domain-specific cognitive differences according to MAPT haplotype. | Versión del editor: | https://doi.org/10.1111/jon.13156 | URI: | http://hdl.handle.net/10261/351443 | DOI: | 10.1111/jon.13156 | ISSN: | 1051-2284 | E-ISSN: | 1552-6569 |
| Aparece en las colecciones: | (CINC) Artículos |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| accesoRestringido.pdf | 59,24 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
1
checked on 28-abr-2024
SCOPUSTM
Citations
1
checked on 01-may-2024
Page view(s)
36
checked on 07-may-2024
Download(s)
1
checked on 07-may-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.